Performance and cutoffs for liver fibrosis staging of a two-dimensional shear wave elastography technique

Giovanna Ferraioli, Laura Maiocchi, Carolina Dellafiore, Carmine Tinelli, Elisabetta Above, Carlo Filice

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To assess performance and cutoffs of the 2-dimensional shear wave elastography technique available on the Aplio i800 ultrasound system (Canon Medical Systems, Japan), using transient elastography as reference standard, and to assess the correlation of shear-wave-speed dispersion with liver fibrosis or steatosis. Methods: This was a single-center cross-sectional study. The correlations between values obtained with transient elastography and 2-dimensional-shear wave elastography, and between shear-wave-speed dispersion and fibrosis or steatosis, were assessed with Pearson's r. The diagnostic performance of the 2-dimensional-shear wave elastography for staging significant fibrosis and severe fibrosis compared to transient elastography was assessed using the area under the receiver operating characteristic curve analysis. Results: Three hundred sixty-seven patients (198 males and 169 females) were studied. There was a high correlation between 2-dimensional-shear wave elastography and transient elastography (r = 0.87, P < 0.0001). The area under the receiver operating characteristics of 2-dimensional-shear wave elastography for staging significant fibrosis (F2) and severe fibrosis (F3-F4), respectively, were 0.97 (95% confidence interval, 0.91-0.98) and 0.97 (95% confidence interval, 0.95-0.99). The best cutoffs for significant fibrosis and severe fibrosis, respectively, were > 7 and > 9 kPa. Shear-wave-speed dispersion showed a high correlation with fibrosis (r = 0.85, P < 0.0001), whereas there was a very weak correlation with steatosis. Conclusions: The results of this study show that this 2-dimensional-shear wave elastography technique is accurate for staging liver fibrosis. Shear-wave-speed dispersion is highly correlated with liver fibrosis but not with steatosis.

Original languageEnglish
Pages (from-to)89-95
Number of pages7
JournalEuropean Journal of Gastroenterology and Hepatology
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • chronic liver disease
  • cirrhosis
  • liver fibrosis
  • liver steatosis
  • shear wave dispersion
  • shear wave elastography
  • transient elastography
  • viral hepatitis
  • viscosity

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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