Performance and role of the breast lesion excision system (BLES) in small clusters of suspicious microcalcifications

Scaperrotta Gianfranco, Ferranti Claudio, Capalbo Emanuela, Paolini Biagio, Marchesini Monica, Suman Laura, Folini Cristina, Mariani Luigi, Panizza Pietro

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose To assess the diagnostic performance of the BLES as a biopsy tool in patients with ≤1 cm clusters of BIRADS 4 microcalcifications, in order to possibly avoid surgical excision in selected patients. Materials This is a retrospective study of 105 patients undergone to stereotactic breast biopsy with the BLES. It excises a single specimen containing the whole mammographic target, allowing better histological assessment due to preserved architecture. Results Our case series consists of 41 carcinomas (39%) and 64 benign lesions (61%). Cancer involved the specimen margins in 20/41 cases (48.8%) or was close to them (≤1 mm) in 14 cases (34.1%); margins were disease-free in only 7 DCIS (17.1%). At subsequent excision of 39/41 malignant cases, underestimation occurred for 5/32 DCIS (15.6%), residual disease was found in 15/39 cancers (38.5%) and no cancer in 19/39 cases (48.7%). For DCIS cases, no residual disease occurred for 66.7% G1-G2 cases and for 35.3% G3 cases (P = 0.1556) as well as in 83.3%, 40.0% and 43.8% cases respectively for negative, close and positive BLES margins (P = 0.2576). Conclusions The BLES is a good option for removal of small clusters of breast microcalcifications, giving better histological interpretation, lower underestimation rates and possibly reducing the need of subsequent surgical excision in selected patients.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalEuropean Journal of Radiology
Volume85
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Calcinosis
Breast
Carcinoma, Intraductal, Noninfiltrating
Biopsy
Neoplasms
Retrospective Studies
Carcinoma

Keywords

  • Breast neoplasms
  • Carcinoma
  • Image-guided biopsy
  • Intraductal
  • Resection margins

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Performance and role of the breast lesion excision system (BLES) in small clusters of suspicious microcalcifications. / Gianfranco, Scaperrotta; Claudio, Ferranti; Emanuela, Capalbo; Biagio, Paolini; Monica, Marchesini; Laura, Suman; Cristina, Folini; Luigi, Mariani; Pietro, Panizza.

In: European Journal of Radiology, Vol. 85, No. 1, 01.01.2016, p. 143-149.

Research output: Contribution to journalArticle

@article{df43651b8bdf4a8088e5e490bad068ba,
title = "Performance and role of the breast lesion excision system (BLES) in small clusters of suspicious microcalcifications",
abstract = "Purpose To assess the diagnostic performance of the BLES as a biopsy tool in patients with ≤1 cm clusters of BIRADS 4 microcalcifications, in order to possibly avoid surgical excision in selected patients. Materials This is a retrospective study of 105 patients undergone to stereotactic breast biopsy with the BLES. It excises a single specimen containing the whole mammographic target, allowing better histological assessment due to preserved architecture. Results Our case series consists of 41 carcinomas (39{\%}) and 64 benign lesions (61{\%}). Cancer involved the specimen margins in 20/41 cases (48.8{\%}) or was close to them (≤1 mm) in 14 cases (34.1{\%}); margins were disease-free in only 7 DCIS (17.1{\%}). At subsequent excision of 39/41 malignant cases, underestimation occurred for 5/32 DCIS (15.6{\%}), residual disease was found in 15/39 cancers (38.5{\%}) and no cancer in 19/39 cases (48.7{\%}). For DCIS cases, no residual disease occurred for 66.7{\%} G1-G2 cases and for 35.3{\%} G3 cases (P = 0.1556) as well as in 83.3{\%}, 40.0{\%} and 43.8{\%} cases respectively for negative, close and positive BLES margins (P = 0.2576). Conclusions The BLES is a good option for removal of small clusters of breast microcalcifications, giving better histological interpretation, lower underestimation rates and possibly reducing the need of subsequent surgical excision in selected patients.",
keywords = "Breast neoplasms, Carcinoma, Image-guided biopsy, Intraductal, Resection margins",
author = "Scaperrotta Gianfranco and Ferranti Claudio and Capalbo Emanuela and Paolini Biagio and Marchesini Monica and Suman Laura and Folini Cristina and Mariani Luigi and Panizza Pietro",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.ejrad.2015.11.001",
language = "English",
volume = "85",
pages = "143--149",
journal = "European Journal of Radiology",
issn = "0720-048X",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Performance and role of the breast lesion excision system (BLES) in small clusters of suspicious microcalcifications

AU - Gianfranco, Scaperrotta

AU - Claudio, Ferranti

AU - Emanuela, Capalbo

AU - Biagio, Paolini

AU - Monica, Marchesini

AU - Laura, Suman

AU - Cristina, Folini

AU - Luigi, Mariani

AU - Pietro, Panizza

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Purpose To assess the diagnostic performance of the BLES as a biopsy tool in patients with ≤1 cm clusters of BIRADS 4 microcalcifications, in order to possibly avoid surgical excision in selected patients. Materials This is a retrospective study of 105 patients undergone to stereotactic breast biopsy with the BLES. It excises a single specimen containing the whole mammographic target, allowing better histological assessment due to preserved architecture. Results Our case series consists of 41 carcinomas (39%) and 64 benign lesions (61%). Cancer involved the specimen margins in 20/41 cases (48.8%) or was close to them (≤1 mm) in 14 cases (34.1%); margins were disease-free in only 7 DCIS (17.1%). At subsequent excision of 39/41 malignant cases, underestimation occurred for 5/32 DCIS (15.6%), residual disease was found in 15/39 cancers (38.5%) and no cancer in 19/39 cases (48.7%). For DCIS cases, no residual disease occurred for 66.7% G1-G2 cases and for 35.3% G3 cases (P = 0.1556) as well as in 83.3%, 40.0% and 43.8% cases respectively for negative, close and positive BLES margins (P = 0.2576). Conclusions The BLES is a good option for removal of small clusters of breast microcalcifications, giving better histological interpretation, lower underestimation rates and possibly reducing the need of subsequent surgical excision in selected patients.

AB - Purpose To assess the diagnostic performance of the BLES as a biopsy tool in patients with ≤1 cm clusters of BIRADS 4 microcalcifications, in order to possibly avoid surgical excision in selected patients. Materials This is a retrospective study of 105 patients undergone to stereotactic breast biopsy with the BLES. It excises a single specimen containing the whole mammographic target, allowing better histological assessment due to preserved architecture. Results Our case series consists of 41 carcinomas (39%) and 64 benign lesions (61%). Cancer involved the specimen margins in 20/41 cases (48.8%) or was close to them (≤1 mm) in 14 cases (34.1%); margins were disease-free in only 7 DCIS (17.1%). At subsequent excision of 39/41 malignant cases, underestimation occurred for 5/32 DCIS (15.6%), residual disease was found in 15/39 cancers (38.5%) and no cancer in 19/39 cases (48.7%). For DCIS cases, no residual disease occurred for 66.7% G1-G2 cases and for 35.3% G3 cases (P = 0.1556) as well as in 83.3%, 40.0% and 43.8% cases respectively for negative, close and positive BLES margins (P = 0.2576). Conclusions The BLES is a good option for removal of small clusters of breast microcalcifications, giving better histological interpretation, lower underestimation rates and possibly reducing the need of subsequent surgical excision in selected patients.

KW - Breast neoplasms

KW - Carcinoma

KW - Image-guided biopsy

KW - Intraductal

KW - Resection margins

UR - http://www.scopus.com/inward/record.url?scp=84955492514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955492514&partnerID=8YFLogxK

U2 - 10.1016/j.ejrad.2015.11.001

DO - 10.1016/j.ejrad.2015.11.001

M3 - Article

VL - 85

SP - 143

EP - 149

JO - European Journal of Radiology

JF - European Journal of Radiology

SN - 0720-048X

IS - 1

ER -