Abstract
Background and objective: Transbronchial needle aspiration (TBNA) is useful for diagnosing peripheral pulmonary lesions (PPL). However, TBNA is largely underused and the variables that may be related to its diagnostic usefulness have not been specifically studied. The aim of the present study was to evaluate the performance characteristics and predictors of yield from TBNA of PPL, and to compare the performance characteristics of different bronchoscopic sampling methods. Methods: Consecutive patients with PPL were prospectively enrolled, and during the same examination, TBNA, transbronchial lung biopsy (TBLB) and bronchial washing (BW) were performed. Results: Two hundred and eighteen PPL in 218 patients were sampled. TBNA was more sensitive (65%) than either TBLB (45%, P <0.001) or BW (22%, P <0.001). TBNA was the only diagnostic procedure in 42/196 patients (21%) with malignant lesions, and was more likely to be the only diagnostic procedure for lesions lacking (23/85 patients, 27%) than for lesions with the bronchus sign (19/111 patients, 17%). In multivariate analysis, a lesion size >2 cm, malignancy and location in the middle lobe were independent predictors of a positive TBNA result. Conclusions: TBNA is the single best contributor to the success of bronchoscopy in the diagnosis of PPLs, and should be routinely used especially in the presence of lesions lacking the bronchus sign. Lesion size of > 2 cm, location in the middle lobe, and malignant nature are strong predictors of a positive TBNA result. In a large series of patients with peripheral pulmonary lesions, transbronchial needle aspiration was the single best method associated with successful diagnosis. Preference should be given to this method, especially for lesions lacking the bronchus sign on CT.
| Original language | English |
|---|---|
| Pages (from-to) | 1144-1149 |
| Number of pages | 6 |
| Journal | Respirology |
| Volume | 16 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Oct 2011 |
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Keywords
- bronchus sign
- lung cancer
- lung nodule
- transbronchial lung biopsy
- transbronchial needle aspiration
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Performance characteristics and predictors of yield from transbronchial needle aspiration in the diagnosis of peripheral pulmonary lesions. / Trisolini, Rocco; Cancellieri, Alessandra; Tinelli, Carmine; Paioli, Daniela; Scudeller, Luigia; Forti Parri, Sergio Nicola; Livi, Vanina; Boaron, Maurizio; Patelli, Marco.
In: Respirology, Vol. 16, No. 7, 10.2011, p. 1144-1149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Performance characteristics and predictors of yield from transbronchial needle aspiration in the diagnosis of peripheral pulmonary lesions
AU - Trisolini, Rocco
AU - Cancellieri, Alessandra
AU - Tinelli, Carmine
AU - Paioli, Daniela
AU - Scudeller, Luigia
AU - Forti Parri, Sergio Nicola
AU - Livi, Vanina
AU - Boaron, Maurizio
AU - Patelli, Marco
PY - 2011/10
Y1 - 2011/10
N2 - Background and objective: Transbronchial needle aspiration (TBNA) is useful for diagnosing peripheral pulmonary lesions (PPL). However, TBNA is largely underused and the variables that may be related to its diagnostic usefulness have not been specifically studied. The aim of the present study was to evaluate the performance characteristics and predictors of yield from TBNA of PPL, and to compare the performance characteristics of different bronchoscopic sampling methods. Methods: Consecutive patients with PPL were prospectively enrolled, and during the same examination, TBNA, transbronchial lung biopsy (TBLB) and bronchial washing (BW) were performed. Results: Two hundred and eighteen PPL in 218 patients were sampled. TBNA was more sensitive (65%) than either TBLB (45%, P <0.001) or BW (22%, P <0.001). TBNA was the only diagnostic procedure in 42/196 patients (21%) with malignant lesions, and was more likely to be the only diagnostic procedure for lesions lacking (23/85 patients, 27%) than for lesions with the bronchus sign (19/111 patients, 17%). In multivariate analysis, a lesion size >2 cm, malignancy and location in the middle lobe were independent predictors of a positive TBNA result. Conclusions: TBNA is the single best contributor to the success of bronchoscopy in the diagnosis of PPLs, and should be routinely used especially in the presence of lesions lacking the bronchus sign. Lesion size of > 2 cm, location in the middle lobe, and malignant nature are strong predictors of a positive TBNA result. In a large series of patients with peripheral pulmonary lesions, transbronchial needle aspiration was the single best method associated with successful diagnosis. Preference should be given to this method, especially for lesions lacking the bronchus sign on CT.
AB - Background and objective: Transbronchial needle aspiration (TBNA) is useful for diagnosing peripheral pulmonary lesions (PPL). However, TBNA is largely underused and the variables that may be related to its diagnostic usefulness have not been specifically studied. The aim of the present study was to evaluate the performance characteristics and predictors of yield from TBNA of PPL, and to compare the performance characteristics of different bronchoscopic sampling methods. Methods: Consecutive patients with PPL were prospectively enrolled, and during the same examination, TBNA, transbronchial lung biopsy (TBLB) and bronchial washing (BW) were performed. Results: Two hundred and eighteen PPL in 218 patients were sampled. TBNA was more sensitive (65%) than either TBLB (45%, P <0.001) or BW (22%, P <0.001). TBNA was the only diagnostic procedure in 42/196 patients (21%) with malignant lesions, and was more likely to be the only diagnostic procedure for lesions lacking (23/85 patients, 27%) than for lesions with the bronchus sign (19/111 patients, 17%). In multivariate analysis, a lesion size >2 cm, malignancy and location in the middle lobe were independent predictors of a positive TBNA result. Conclusions: TBNA is the single best contributor to the success of bronchoscopy in the diagnosis of PPLs, and should be routinely used especially in the presence of lesions lacking the bronchus sign. Lesion size of > 2 cm, location in the middle lobe, and malignant nature are strong predictors of a positive TBNA result. In a large series of patients with peripheral pulmonary lesions, transbronchial needle aspiration was the single best method associated with successful diagnosis. Preference should be given to this method, especially for lesions lacking the bronchus sign on CT.
KW - bronchus sign
KW - lung cancer
KW - lung nodule
KW - transbronchial lung biopsy
KW - transbronchial needle aspiration
UR - http://www.scopus.com/inward/record.url?scp=80053311611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053311611&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1843.2011.02026.x
DO - 10.1111/j.1440-1843.2011.02026.x
M3 - Article
C2 - 21801276
AN - SCOPUS:80053311611
VL - 16
SP - 1144
EP - 1149
JO - Respirology
JF - Respirology
SN - 1323-7799
IS - 7
ER -