Performance of a new needle for endoscopic ultrasound-guided fine-needle biopsy in patients with pancreatic solid lesions: A retrospective multicenter study

Roberto Di Mitri, Mihai Rimbaş, Fabia Attili, Carlo Fabbri, Silvia Carrara, Luca Di Maurizio, Frediano Inzani, Alessandro Repici, Antonio Gasbarrini, Guido Costamagna, Alberto Larghi

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND OBJECTIVES: Procurement of tissue core biopsy samples may overcome some of the limitations of endoscopic ultrasound (EUS)-guided fine-needle aspiration. We aimed at assessing the safety, histological sample procurement yield, and diagnostic accuracy of a newly available histology needle.

MATERIALS AND METHODS: Data from consecutive patients with pancreatic solid lesions who underwent EUS-fine needle biopsy (EUS-FNB) using the 22-gauge Acquire™ needle were retrospectively retrieved from four tertiary care centers database.

RESULTS: Fifty-nine patients (mean age 68 ± 12 years; male/female 29/30) with pancreatic solid lesions underwent EUS-FNB using the 22-gauge Acquire™ needle. The biopsy was done transgastrically in 22 (37.3%) patients and transduodenally in 37 (62.7%) cases. A mean of 2.8 ± 0.45 needle passes per lesion site were performed, without any major complication. A tissue core biopsy sample for histological evaluation was obtained in 55 (93.2%) cases. In the additional four cases, the specimen obtained resulted adequate for cytological evaluation. Considering malignant versus nonmalignant disease, sensitivity, specificity, negative likelihood ratio, positive likelihood ratio, and diagnostic accuracy were 98.2% (95% confidence interval [CI], 90.6-99.7), 100% (95% CI, 43.6-100), 0.018 (95% CI, 0.003-0.125), 295.6 (95% CI, 0-9.3 × 1010), and 98.3% (95% CI, 94.9-100), respectively.

CONCLUSIONS: EUS-FNB using the 22-gauge Acquire™ needle is able to reach a very high procurement yield and diagnostic accuracy. Large prospective studies are warranted to further evaluate the utility of this newly developed needle.

Original languageEnglish
JournalEndoscopic Ultrasound
DOIs
Publication statusE-pub ahead of print - Aug 24 2017

Fingerprint

Fine Needle Biopsy
Multicenter Studies
Needles
Retrospective Studies
Confidence Intervals
Biopsy
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Tissue and Organ Procurement
Tertiary Care Centers
Histology
Databases
Prospective Studies
Safety
Sensitivity and Specificity

Keywords

  • Journal Article

Cite this

Performance of a new needle for endoscopic ultrasound-guided fine-needle biopsy in patients with pancreatic solid lesions : A retrospective multicenter study. / Mitri, Roberto Di; Rimbaş, Mihai; Attili, Fabia; Fabbri, Carlo; Carrara, Silvia; Di Maurizio, Luca; Inzani, Frediano; Repici, Alessandro; Gasbarrini, Antonio; Costamagna, Guido; Larghi, Alberto.

In: Endoscopic Ultrasound, 24.08.2017.

Research output: Contribution to journalArticle

Mitri, Roberto Di ; Rimbaş, Mihai ; Attili, Fabia ; Fabbri, Carlo ; Carrara, Silvia ; Di Maurizio, Luca ; Inzani, Frediano ; Repici, Alessandro ; Gasbarrini, Antonio ; Costamagna, Guido ; Larghi, Alberto. / Performance of a new needle for endoscopic ultrasound-guided fine-needle biopsy in patients with pancreatic solid lesions : A retrospective multicenter study. In: Endoscopic Ultrasound. 2017.
@article{6b090fb42c884751bb2424db9d5c93e2,
title = "Performance of a new needle for endoscopic ultrasound-guided fine-needle biopsy in patients with pancreatic solid lesions: A retrospective multicenter study",
abstract = "BACKGROUND AND OBJECTIVES: Procurement of tissue core biopsy samples may overcome some of the limitations of endoscopic ultrasound (EUS)-guided fine-needle aspiration. We aimed at assessing the safety, histological sample procurement yield, and diagnostic accuracy of a newly available histology needle.MATERIALS AND METHODS: Data from consecutive patients with pancreatic solid lesions who underwent EUS-fine needle biopsy (EUS-FNB) using the 22-gauge Acquire™ needle were retrospectively retrieved from four tertiary care centers database.RESULTS: Fifty-nine patients (mean age 68 ± 12 years; male/female 29/30) with pancreatic solid lesions underwent EUS-FNB using the 22-gauge Acquire™ needle. The biopsy was done transgastrically in 22 (37.3{\%}) patients and transduodenally in 37 (62.7{\%}) cases. A mean of 2.8 ± 0.45 needle passes per lesion site were performed, without any major complication. A tissue core biopsy sample for histological evaluation was obtained in 55 (93.2{\%}) cases. In the additional four cases, the specimen obtained resulted adequate for cytological evaluation. Considering malignant versus nonmalignant disease, sensitivity, specificity, negative likelihood ratio, positive likelihood ratio, and diagnostic accuracy were 98.2{\%} (95{\%} confidence interval [CI], 90.6-99.7), 100{\%} (95{\%} CI, 43.6-100), 0.018 (95{\%} CI, 0.003-0.125), 295.6 (95{\%} CI, 0-9.3 × 1010), and 98.3{\%} (95{\%} CI, 94.9-100), respectively.CONCLUSIONS: EUS-FNB using the 22-gauge Acquire™ needle is able to reach a very high procurement yield and diagnostic accuracy. Large prospective studies are warranted to further evaluate the utility of this newly developed needle.",
keywords = "Journal Article",
author = "Mitri, {Roberto Di} and Mihai Rimbaş and Fabia Attili and Carlo Fabbri and Silvia Carrara and {Di Maurizio}, Luca and Frediano Inzani and Alessandro Repici and Antonio Gasbarrini and Guido Costamagna and Alberto Larghi",
year = "2017",
month = "8",
day = "24",
doi = "10.4103/eus.eus_33_17",
language = "English",
journal = "Endoscopic Ultrasound",
issn = "2303-9027",
publisher = "Medknow Publications and Media Pvt. Ltd",

}

TY - JOUR

T1 - Performance of a new needle for endoscopic ultrasound-guided fine-needle biopsy in patients with pancreatic solid lesions

T2 - A retrospective multicenter study

AU - Mitri, Roberto Di

AU - Rimbaş, Mihai

AU - Attili, Fabia

AU - Fabbri, Carlo

AU - Carrara, Silvia

AU - Di Maurizio, Luca

AU - Inzani, Frediano

AU - Repici, Alessandro

AU - Gasbarrini, Antonio

AU - Costamagna, Guido

AU - Larghi, Alberto

PY - 2017/8/24

Y1 - 2017/8/24

N2 - BACKGROUND AND OBJECTIVES: Procurement of tissue core biopsy samples may overcome some of the limitations of endoscopic ultrasound (EUS)-guided fine-needle aspiration. We aimed at assessing the safety, histological sample procurement yield, and diagnostic accuracy of a newly available histology needle.MATERIALS AND METHODS: Data from consecutive patients with pancreatic solid lesions who underwent EUS-fine needle biopsy (EUS-FNB) using the 22-gauge Acquire™ needle were retrospectively retrieved from four tertiary care centers database.RESULTS: Fifty-nine patients (mean age 68 ± 12 years; male/female 29/30) with pancreatic solid lesions underwent EUS-FNB using the 22-gauge Acquire™ needle. The biopsy was done transgastrically in 22 (37.3%) patients and transduodenally in 37 (62.7%) cases. A mean of 2.8 ± 0.45 needle passes per lesion site were performed, without any major complication. A tissue core biopsy sample for histological evaluation was obtained in 55 (93.2%) cases. In the additional four cases, the specimen obtained resulted adequate for cytological evaluation. Considering malignant versus nonmalignant disease, sensitivity, specificity, negative likelihood ratio, positive likelihood ratio, and diagnostic accuracy were 98.2% (95% confidence interval [CI], 90.6-99.7), 100% (95% CI, 43.6-100), 0.018 (95% CI, 0.003-0.125), 295.6 (95% CI, 0-9.3 × 1010), and 98.3% (95% CI, 94.9-100), respectively.CONCLUSIONS: EUS-FNB using the 22-gauge Acquire™ needle is able to reach a very high procurement yield and diagnostic accuracy. Large prospective studies are warranted to further evaluate the utility of this newly developed needle.

AB - BACKGROUND AND OBJECTIVES: Procurement of tissue core biopsy samples may overcome some of the limitations of endoscopic ultrasound (EUS)-guided fine-needle aspiration. We aimed at assessing the safety, histological sample procurement yield, and diagnostic accuracy of a newly available histology needle.MATERIALS AND METHODS: Data from consecutive patients with pancreatic solid lesions who underwent EUS-fine needle biopsy (EUS-FNB) using the 22-gauge Acquire™ needle were retrospectively retrieved from four tertiary care centers database.RESULTS: Fifty-nine patients (mean age 68 ± 12 years; male/female 29/30) with pancreatic solid lesions underwent EUS-FNB using the 22-gauge Acquire™ needle. The biopsy was done transgastrically in 22 (37.3%) patients and transduodenally in 37 (62.7%) cases. A mean of 2.8 ± 0.45 needle passes per lesion site were performed, without any major complication. A tissue core biopsy sample for histological evaluation was obtained in 55 (93.2%) cases. In the additional four cases, the specimen obtained resulted adequate for cytological evaluation. Considering malignant versus nonmalignant disease, sensitivity, specificity, negative likelihood ratio, positive likelihood ratio, and diagnostic accuracy were 98.2% (95% confidence interval [CI], 90.6-99.7), 100% (95% CI, 43.6-100), 0.018 (95% CI, 0.003-0.125), 295.6 (95% CI, 0-9.3 × 1010), and 98.3% (95% CI, 94.9-100), respectively.CONCLUSIONS: EUS-FNB using the 22-gauge Acquire™ needle is able to reach a very high procurement yield and diagnostic accuracy. Large prospective studies are warranted to further evaluate the utility of this newly developed needle.

KW - Journal Article

U2 - 10.4103/eus.eus_33_17

DO - 10.4103/eus.eus_33_17

M3 - Article

C2 - 28836520

JO - Endoscopic Ultrasound

JF - Endoscopic Ultrasound

SN - 2303-9027

ER -