Performance of cytology and colposcopy in diagnosis of cervical intraepithelial neoplasia (CIN) in HIV-positive and HIV-negative women

M. Branca, E. Rossi, M. Alderisio, G. Migliore, P. L. Morosini, A. Vecchione, F. Sopracordevole, P. Mudu, L. Leoncini, K. Syrjänen

Research output: Contribution to journalArticle

Abstract

As part of an extensive multi-institutional DIANAIDS-HIV-HPV-SIL project run in Italy (co-ordinated by ISS), the present study compares the performance (sensitivity, specificity, agreement) of routine cervical smear cytology with that of colposcopy in the detection of histologically-confirmed CIN lesions in 37 HIV-positive and 21 HIVnegative women, belonging to the DIANAIDS cohort of 459 women. All women were subjected to a cervical smear, colposcopy and biopsy, making possible the pairwise comparison of these techniques. In the whole series of HIV-positive and HIV-negative women, cytology had a sensitivity of 86.9% and specificity of 83.3%, the sensitivity of grade 2 abnormality on colposcopy against histology being 82.6% and specificity, 33.3%. No statistically significant difference was observed in the performance of Pap smears between the HIV-positive and HIV-negative women. The sensitivity of cytology was 89.7% vs 82.4% and the specificity, 75% vs 100%. For colposcopy, the sensitivity was 79.3% vs 88.2% and the specificity, 75% vs 50%. These data suggest that cervical Pap smear cytology is a highly sensitive and specific diagnostic tool in the clinical monitoring of lower genital tract pathology in HIV-positive women. Colposcopy, on the other hand, proved to be a somewhat less accurate diagnostic tool in these women.

Original languageEnglish
Pages (from-to)84-93
Number of pages10
JournalCytopathology
Volume12
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • CIN
  • Colposcopy
  • Histology
  • HIV
  • HPV
  • Pap smear
  • Test performance

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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    Branca, M., Rossi, E., Alderisio, M., Migliore, G., Morosini, P. L., Vecchione, A., Sopracordevole, F., Mudu, P., Leoncini, L., & Syrjänen, K. (2001). Performance of cytology and colposcopy in diagnosis of cervical intraepithelial neoplasia (CIN) in HIV-positive and HIV-negative women. Cytopathology, 12(2), 84-93. https://doi.org/10.1046/j.1365-2303.2001.00299.x