Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis: Journal of Infection

M. Bassetti; D.R. Giacobbe; C. Grecchi; C. Rebuffi; V. Zuccaro; L. Scudeller; M. Akova; A. Alastruey-Izquierdo; S. Arikan-Akdagli; E. Azoulay; S. Blot; O.A. Cornely; C. Lass-Flörl; P. Koehler; M. Cuenca-Estrella; D.W. de Lange; F.G. De Rosa; J.J. De Waele; G. Dimopoulos; J. Garnacho-Montero; M. Hoenigl; S.S. Kanj; F. Lamoth; J. Maertens; I. Martin-Loeches; P. Muñoz; B.J. Kullberg; C. Agvald-Ohman; G. Poulakou; J. Rello; E. Righi; M. Sanguinetti; F.S. Taccone; J.-F. Timsit; A. Torres; J.A. Vazquez; J. Wauters; T. Calandra; E. Asperges; S. Tejada; C. Lebihan; I. Karaiskos; M. Peghin; K.L. Mortensen; A. Vena; A. Cortegiani; T. Mercier; the FUNDICU investigators

doi:10.1016/j.jinf.2020.03.065

Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis: Journal of Infection

M. Bassetti, D.R. Giacobbe, C. Grecchi, C. Rebuffi, V. Zuccaro, L. Scudeller, M. Akova, A. Alastruey-Izquierdo, S. Arikan-Akdagli, E. Azoulay, S. Blot, O.A. Cornely, C. Lass-Flörl, P. Koehler, M. Cuenca-Estrella, D.W. de Lange, F.G. De Rosa, J.J. De Waele, G. Dimopoulos, J. Garnacho-MonteroM. Hoenigl, S.S. Kanj, F. Lamoth, J. Maertens, I. Martin-Loeches, P. Muñoz, B.J. Kullberg, C. Agvald-Ohman, G. Poulakou, J. Rello, E. Righi, M. Sanguinetti, F.S. Taccone, J.-F. Timsit, A. Torres, J.A. Vazquez, J. Wauters, T. Calandra, E. Asperges, S. Tejada, C. Lebihan, I. Karaiskos, M. Peghin, K.L. Mortensen, A. Vena, A. Cortegiani, T. Mercier, the FUNDICU investigators

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: To summarize the available evidence on the diagnostic performance for invasive aspergillosis (IA) in non-hematological, non-solid organ transplantation critically ill patients of the following: (i) existing definitions of IA (developed either for classical immunocompromised populations or for non-immunocompromised critically ill patients); (ii) laboratory tests; (iii) radiology tests. Methods: A systematic review was performed by evaluating studies assessing the diagnostic performance for IA of a definition/s and/or laboratory/radiology test/s vs. a reference standard (histology) or a reference definition. Results: Sufficient data for evaluating the performance of existing definitions and laboratory tests for the diagnosis of IA in critically ill patients is available only for invasive pulmonary aspergillosis. Against histology/autopsy as reference, the AspICU definition showed a promising diagnostic performance but based on small samples and applicable only to patients with positive respiratory cultures. Studies on laboratory tests consistently indicated a better diagnostic performance of bronchoalveolar lavage fluid (BALF) galactomannan (GM) than serum GM, and a suboptimal specificity of BALF and serum (1,3)-β-D-glucan. Conclusions: Evidence stemming from this systematic review will guide the discussion for defining invasive aspergillosis within the FUNDICU project. The project aims to develop a standard set of definitions for invasive fungal diseases in critically ill, adult patients.

Original language	English
Pages (from-to)	131-146
Number of pages	16
Journal	J. Infect.
Volume	81
Issue number	1
DOIs	https://doi.org/10.1016/j.jinf.2020.03.065
Publication status	Published - 2020

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10.1016/j.jinf.2020.03.065

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Bassetti, M., Giacobbe, D. R., Grecchi, C., Rebuffi, C., Zuccaro, V., Scudeller, L., Akova, M., Alastruey-Izquierdo, A., Arikan-Akdagli, S., Azoulay, E., Blot, S., Cornely, O. A., Lass-Flörl, C., Koehler, P., Cuenca-Estrella, M., de Lange, D. W., De Rosa, F. G., De Waele, J. J., Dimopoulos, G., ... investigators, T. FUNDICU. (2020). Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis: Journal of Infection. J. Infect., 81(1), 131-146. https://doi.org/10.1016/j.jinf.2020.03.065

Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis : Journal of Infection. / Bassetti, M.; Giacobbe, D.R.; Grecchi, C.; Rebuffi, C.; Zuccaro, V.; Scudeller, L.; Akova, M.; Alastruey-Izquierdo, A.; Arikan-Akdagli, S.; Azoulay, E.; Blot, S.; Cornely, O.A.; Lass-Flörl, C.; Koehler, P.; Cuenca-Estrella, M.; de Lange, D.W.; De Rosa, F.G.; De Waele, J.J.; Dimopoulos, G.; Garnacho-Montero, J.; Hoenigl, M.; Kanj, S.S.; Lamoth, F.; Maertens, J.; Martin-Loeches, I.; Muñoz, P.; Kullberg, B.J.; Agvald-Ohman, C.; Poulakou, G.; Rello, J.; Righi, E.; Sanguinetti, M.; Taccone, F.S.; Timsit, J.-F.; Torres, A.; Vazquez, J.A.; Wauters, J.; Calandra, T.; Asperges, E.; Tejada, S.; Lebihan, C.; Karaiskos, I.; Peghin, M.; Mortensen, K.L.; Vena, A.; Cortegiani, A.; Mercier, T.; investigators, the FUNDICU.

In: J. Infect., Vol. 81, No. 1, 2020, p. 131-146.

Research output: Contribution to journal › Article › peer-review

Bassetti, M , Giacobbe, DR, Grecchi, C, Rebuffi, C, Zuccaro, V, Scudeller, L, Akova, M, Alastruey-Izquierdo, A, Arikan-Akdagli, S, Azoulay, E, Blot, S, Cornely, OA, Lass-Flörl, C, Koehler, P, Cuenca-Estrella, M, de Lange, DW, De Rosa, FG, De Waele, JJ, Dimopoulos, G, Garnacho-Montero, J, Hoenigl, M, Kanj, SS, Lamoth, F, Maertens, J, Martin-Loeches, I, Muñoz, P, Kullberg, BJ, Agvald-Ohman, C, Poulakou, G, Rello, J, Righi, E, Sanguinetti, M, Taccone, FS, Timsit, J-F, Torres, A, Vazquez, JA, Wauters, J, Calandra, T, Asperges, E, Tejada, S, Lebihan, C, Karaiskos, I, Peghin, M, Mortensen, KL, Vena, A, Cortegiani, A, Mercier, T & investigators, TFUNDICU 2020, 'Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis: Journal of Infection', J. Infect., vol. 81, no. 1, pp. 131-146. https://doi.org/10.1016/j.jinf.2020.03.065

Bassetti, M. ; Giacobbe, D.R. ; Grecchi, C. ; Rebuffi, C. ; Zuccaro, V. ; Scudeller, L. ; Akova, M. ; Alastruey-Izquierdo, A. ; Arikan-Akdagli, S. ; Azoulay, E. ; Blot, S. ; Cornely, O.A. ; Lass-Flörl, C. ; Koehler, P. ; Cuenca-Estrella, M. ; de Lange, D.W. ; De Rosa, F.G. ; De Waele, J.J. ; Dimopoulos, G. ; Garnacho-Montero, J. ; Hoenigl, M. ; Kanj, S.S. ; Lamoth, F. ; Maertens, J. ; Martin-Loeches, I. ; Muñoz, P. ; Kullberg, B.J. ; Agvald-Ohman, C. ; Poulakou, G. ; Rello, J. ; Righi, E. ; Sanguinetti, M. ; Taccone, F.S. ; Timsit, J.-F. ; Torres, A. ; Vazquez, J.A. ; Wauters, J. ; Calandra, T. ; Asperges, E. ; Tejada, S. ; Lebihan, C. ; Karaiskos, I. ; Peghin, M. ; Mortensen, K.L. ; Vena, A. ; Cortegiani, A. ; Mercier, T. ; investigators, the FUNDICU. / Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis : Journal of Infection. In: J. Infect. 2020 ; Vol. 81, No. 1. pp. 131-146.

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title = "Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis: Journal of Infection",

abstract = "Objectives: To summarize the available evidence on the diagnostic performance for invasive aspergillosis (IA) in non-hematological, non-solid organ transplantation critically ill patients of the following: (i) existing definitions of IA (developed either for classical immunocompromised populations or for non-immunocompromised critically ill patients); (ii) laboratory tests; (iii) radiology tests. Methods: A systematic review was performed by evaluating studies assessing the diagnostic performance for IA of a definition/s and/or laboratory/radiology test/s vs. a reference standard (histology) or a reference definition. Results: Sufficient data for evaluating the performance of existing definitions and laboratory tests for the diagnosis of IA in critically ill patients is available only for invasive pulmonary aspergillosis. Against histology/autopsy as reference, the AspICU definition showed a promising diagnostic performance but based on small samples and applicable only to patients with positive respiratory cultures. Studies on laboratory tests consistently indicated a better diagnostic performance of bronchoalveolar lavage fluid (BALF) galactomannan (GM) than serum GM, and a suboptimal specificity of BALF and serum (1,3)-β-D-glucan. Conclusions: Evidence stemming from this systematic review will guide the discussion for defining invasive aspergillosis within the FUNDICU project. The project aims to develop a standard set of definitions for invasive fungal diseases in critically ill, adult patients.",

author = "M. Bassetti and D.R. Giacobbe and C. Grecchi and C. Rebuffi and V. Zuccaro and L. Scudeller and M. Akova and A. Alastruey-Izquierdo and S. Arikan-Akdagli and E. Azoulay and S. Blot and O.A. Cornely and C. Lass-Fl{\"o}rl and P. Koehler and M. Cuenca-Estrella and {de Lange}, D.W. and {De Rosa}, F.G. and {De Waele}, J.J. and G. Dimopoulos and J. Garnacho-Montero and M. Hoenigl and S.S. Kanj and F. Lamoth and J. Maertens and I. Martin-Loeches and P. Mu{\~n}oz and B.J. Kullberg and C. Agvald-Ohman and G. Poulakou and J. Rello and E. Righi and M. Sanguinetti and F.S. Taccone and J.-F. Timsit and A. Torres and J.A. Vazquez and J. Wauters and T. Calandra and E. Asperges and S. Tejada and C. Lebihan and I. Karaiskos and M. Peghin and K.L. Mortensen and A. Vena and A. Cortegiani and T. Mercier and investigators, {the FUNDICU}",

note = "Cited By :12 Export Date: 17 February 2021 CODEN: JINFD Correspondence Address: Bassetti, M.; Clinica Malattie Infettive, L.go R. Benzi 10, Italy; email: matteo.bassetti@unige.it",

year = "2020",

doi = "10.1016/j.jinf.2020.03.065",

language = "English",

volume = "81",

pages = "131--146",

journal = "J. Infect.",

issn = "0163-4453",

publisher = "W.B. Saunders Ltd",

number = "1",

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TY - JOUR

T1 - Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis

T2 - Journal of Infection

AU - Bassetti, M.

AU - Giacobbe, D.R.

AU - Grecchi, C.

AU - Rebuffi, C.

AU - Zuccaro, V.

AU - Scudeller, L.

AU - Akova, M.

AU - Alastruey-Izquierdo, A.

AU - Arikan-Akdagli, S.

AU - Azoulay, E.

AU - Blot, S.

AU - Cornely, O.A.

AU - Lass-Flörl, C.

AU - Koehler, P.

AU - Cuenca-Estrella, M.

AU - de Lange, D.W.

AU - De Rosa, F.G.

AU - De Waele, J.J.

AU - Dimopoulos, G.

AU - Garnacho-Montero, J.

AU - Hoenigl, M.

AU - Kanj, S.S.

AU - Lamoth, F.

AU - Maertens, J.

AU - Martin-Loeches, I.

AU - Muñoz, P.

AU - Kullberg, B.J.

AU - Agvald-Ohman, C.

AU - Poulakou, G.

AU - Rello, J.

AU - Righi, E.

AU - Sanguinetti, M.

AU - Taccone, F.S.

AU - Timsit, J.-F.

AU - Torres, A.

AU - Vazquez, J.A.

AU - Wauters, J.

AU - Calandra, T.

AU - Asperges, E.

AU - Tejada, S.

AU - Lebihan, C.

AU - Karaiskos, I.

AU - Peghin, M.

AU - Mortensen, K.L.

AU - Vena, A.

AU - Cortegiani, A.

AU - Mercier, T.

AU - investigators, the FUNDICU

N1 - Cited By :12 Export Date: 17 February 2021 CODEN: JINFD Correspondence Address: Bassetti, M.; Clinica Malattie Infettive, L.go R. Benzi 10, Italy; email: matteo.bassetti@unige.it

PY - 2020

Y1 - 2020

N2 - Objectives: To summarize the available evidence on the diagnostic performance for invasive aspergillosis (IA) in non-hematological, non-solid organ transplantation critically ill patients of the following: (i) existing definitions of IA (developed either for classical immunocompromised populations or for non-immunocompromised critically ill patients); (ii) laboratory tests; (iii) radiology tests. Methods: A systematic review was performed by evaluating studies assessing the diagnostic performance for IA of a definition/s and/or laboratory/radiology test/s vs. a reference standard (histology) or a reference definition. Results: Sufficient data for evaluating the performance of existing definitions and laboratory tests for the diagnosis of IA in critically ill patients is available only for invasive pulmonary aspergillosis. Against histology/autopsy as reference, the AspICU definition showed a promising diagnostic performance but based on small samples and applicable only to patients with positive respiratory cultures. Studies on laboratory tests consistently indicated a better diagnostic performance of bronchoalveolar lavage fluid (BALF) galactomannan (GM) than serum GM, and a suboptimal specificity of BALF and serum (1,3)-β-D-glucan. Conclusions: Evidence stemming from this systematic review will guide the discussion for defining invasive aspergillosis within the FUNDICU project. The project aims to develop a standard set of definitions for invasive fungal diseases in critically ill, adult patients.

AB - Objectives: To summarize the available evidence on the diagnostic performance for invasive aspergillosis (IA) in non-hematological, non-solid organ transplantation critically ill patients of the following: (i) existing definitions of IA (developed either for classical immunocompromised populations or for non-immunocompromised critically ill patients); (ii) laboratory tests; (iii) radiology tests. Methods: A systematic review was performed by evaluating studies assessing the diagnostic performance for IA of a definition/s and/or laboratory/radiology test/s vs. a reference standard (histology) or a reference definition. Results: Sufficient data for evaluating the performance of existing definitions and laboratory tests for the diagnosis of IA in critically ill patients is available only for invasive pulmonary aspergillosis. Against histology/autopsy as reference, the AspICU definition showed a promising diagnostic performance but based on small samples and applicable only to patients with positive respiratory cultures. Studies on laboratory tests consistently indicated a better diagnostic performance of bronchoalveolar lavage fluid (BALF) galactomannan (GM) than serum GM, and a suboptimal specificity of BALF and serum (1,3)-β-D-glucan. Conclusions: Evidence stemming from this systematic review will guide the discussion for defining invasive aspergillosis within the FUNDICU project. The project aims to develop a standard set of definitions for invasive fungal diseases in critically ill, adult patients.

U2 - 10.1016/j.jinf.2020.03.065

DO - 10.1016/j.jinf.2020.03.065

M3 - Article

VL - 81

SP - 131

EP - 146

JO - J. Infect.

JF - J. Infect.

SN - 0163-4453

IS - 1

ER -

Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis: Journal of Infection

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