TY - JOUR
T1 - Performance of fineneedle aspiration cytology of the breast. Clinical experience in Ravenna (Italy)
AU - Bucchi, L.
AU - Schincaglia, P.
AU - Melandri, G.
AU - Morini, N.
AU - Naldoni, C.
AU - Serafini, M.
AU - Buzzi, G.
PY - 1993
Y1 - 1993
N2 - Aims and background: Fineneedle aspiration cytology (FNAC) is a routine test in the evaluation of breast lesions. We assessed the diagnostic accuracy of mammography (MG), physical examination (PE), ultrasonography (US) and FNAC in 1064 histologically confirmed breast lesions (638 malignant, 426 benign) observed consecutively at the Cancer Prevention Center of Ravenna (Italy). Methods: The performance of each test and the additional contribution of FNAC were determined. Results: FNAC was done in 69.6% of cancers and 39.7% of benign lesions (P = 0.00000), the frequency of aspiration being significantly associated with severity at MG, PE, and US. For FNAC, the true positive rate was 95.1% and the true negative rate 67.4%. Only one breast cancer case was detected by FNAC alone (additional true positive rate 0.2%). The positive predictive value of FNAC in the absence of other abnormalities was 5%. The negative predictive value of a benign report at MG, PE, US and FNAC was 100%. Conclusions: All breast lesions should be evaluated by all available techniques, especially FNAC, and open biopsy should be avoided for those reported as benign at all tests.
AB - Aims and background: Fineneedle aspiration cytology (FNAC) is a routine test in the evaluation of breast lesions. We assessed the diagnostic accuracy of mammography (MG), physical examination (PE), ultrasonography (US) and FNAC in 1064 histologically confirmed breast lesions (638 malignant, 426 benign) observed consecutively at the Cancer Prevention Center of Ravenna (Italy). Methods: The performance of each test and the additional contribution of FNAC were determined. Results: FNAC was done in 69.6% of cancers and 39.7% of benign lesions (P = 0.00000), the frequency of aspiration being significantly associated with severity at MG, PE, and US. For FNAC, the true positive rate was 95.1% and the true negative rate 67.4%. Only one breast cancer case was detected by FNAC alone (additional true positive rate 0.2%). The positive predictive value of FNAC in the absence of other abnormalities was 5%. The negative predictive value of a benign report at MG, PE, US and FNAC was 100%. Conclusions: All breast lesions should be evaluated by all available techniques, especially FNAC, and open biopsy should be avoided for those reported as benign at all tests.
KW - breast diseases
KW - diagnosis
KW - fineneedle aspiration cytology
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M3 - Article
C2 - 8171742
AN - SCOPUS:0027891822
VL - 79
SP - 413
EP - 417
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 6
ER -