Performance of liver stiffness measurements by transient elastography in chronic hepatitis

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Abstract

AIM: To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used in a recently published meta-analysis. METHODS: This was a single center cross-sectional study. Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled. TE was carried out by using FibroScan™ (Echosens, Paris, France). Liver biopsy was performed on the same day as TE, as day case procedure. Fibrosis was staged according to the Metavir scoring system. The diagnostic performance of TE was assessed by using receiver operating characteristic (ROC) curves and the area under the ROC curve analysis. RESULTS: Two hundred and fifty-two patients met the inclusion criteria. Six (2%) patients were excluded due to unreliable TE measurements. Thus, 246 (171 men and 75 women) patients were analyzed. One hundred and ninety-five (79.3%) patients had chronic hepatitis C, 41 (16.7%) had chronic hepatitis B, and 10 (4.0%) were coinfected with human immunodeficiency virus. ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa for F ≥ 2; 7.9 kPa for F ≥ 3; 9.6 kPa for F = 4 in all patients (n = 246), and as high as 6.9 kPa for F ≥ 2; 7.3 kPa for F ≥ 3; 9.3 kPa for F = 4 in patients with hepatitis C (n = 195). Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2; 9.6 kPa for F ≥ 3; 12.2 kPa for F = 4 in all patients (n = 246), and as high as 7.0 kPa for F ≥ 2; 9.3 kPa for F ≥ 3; 12.3 kPa for F = 4 in patients with hepatitis C (n = 195). CONCLUSION: The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalWorld Journal of Gastroenterology
Volume19
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Elasticity Imaging Techniques
Chronic Hepatitis
Liver
ROC Curve
Hepatitis C
Meta-Analysis
Biopsy
Chronic Hepatitis B
Paris
Chronic Hepatitis C
France
Area Under Curve
Communicable Diseases
Fibrosis
Outpatients
Cross-Sectional Studies
HIV

Keywords

  • Chronic viral hepatitis
  • Elastography
  • Fibroscan
  • Hepatitis c
  • Liver
  • Liver biopsy
  • Liver fibrosis
  • Transient elastography
  • Ultrasound

ASJC Scopus subject areas

  • Gastroenterology

Cite this

@article{cce0e368e8f647e99e1fd1576d722e5b,
title = "Performance of liver stiffness measurements by transient elastography in chronic hepatitis",
abstract = "AIM: To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used in a recently published meta-analysis. METHODS: This was a single center cross-sectional study. Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled. TE was carried out by using FibroScan™ (Echosens, Paris, France). Liver biopsy was performed on the same day as TE, as day case procedure. Fibrosis was staged according to the Metavir scoring system. The diagnostic performance of TE was assessed by using receiver operating characteristic (ROC) curves and the area under the ROC curve analysis. RESULTS: Two hundred and fifty-two patients met the inclusion criteria. Six (2{\%}) patients were excluded due to unreliable TE measurements. Thus, 246 (171 men and 75 women) patients were analyzed. One hundred and ninety-five (79.3{\%}) patients had chronic hepatitis C, 41 (16.7{\%}) had chronic hepatitis B, and 10 (4.0{\%}) were coinfected with human immunodeficiency virus. ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa for F ≥ 2; 7.9 kPa for F ≥ 3; 9.6 kPa for F = 4 in all patients (n = 246), and as high as 6.9 kPa for F ≥ 2; 7.3 kPa for F ≥ 3; 9.3 kPa for F = 4 in patients with hepatitis C (n = 195). Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2; 9.6 kPa for F ≥ 3; 12.2 kPa for F = 4 in all patients (n = 246), and as high as 7.0 kPa for F ≥ 2; 9.3 kPa for F ≥ 3; 12.3 kPa for F = 4 in patients with hepatitis C (n = 195). CONCLUSION: The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies.",
keywords = "Chronic viral hepatitis, Elastography, Fibroscan, Hepatitis c, Liver, Liver biopsy, Liver fibrosis, Transient elastography, Ultrasound",
author = "Giovanna Ferraioli and Carmine Tinelli and {dal Bello}, Barbara and Mabel Zicchetti and Raffaella Lissandrin and Gaetano Filice and Carlo Filice and Elisabetta Above and Giorgio Barbarini and Enrico Brunetti and Willy Calderon and Gregorio, {Marta Di} and Roberto Gulminetti and Paolo Lanzarini and Serena Ludovisi and Laura Maiocchi and Antonello Malfitano and Giuseppe Michelone and Lorenzo Minoli and Mario Mondelli and Stefano Novati and Patruno, {Savino F A} and Alessandro Perretti and Gianluigi Poma and Paolo Sacchi and Domenico Zanaboni and Marco Zaramella",
year = "2013",
doi = "10.3748/wjg.v19.i1.49",
language = "English",
volume = "19",
pages = "49--56",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "1",

}

TY - JOUR

T1 - Performance of liver stiffness measurements by transient elastography in chronic hepatitis

AU - Ferraioli, Giovanna

AU - Tinelli, Carmine

AU - dal Bello, Barbara

AU - Zicchetti, Mabel

AU - Lissandrin, Raffaella

AU - Filice, Gaetano

AU - Filice, Carlo

AU - Above, Elisabetta

AU - Barbarini, Giorgio

AU - Brunetti, Enrico

AU - Calderon, Willy

AU - Gregorio, Marta Di

AU - Gulminetti, Roberto

AU - Lanzarini, Paolo

AU - Ludovisi, Serena

AU - Maiocchi, Laura

AU - Malfitano, Antonello

AU - Michelone, Giuseppe

AU - Minoli, Lorenzo

AU - Mondelli, Mario

AU - Novati, Stefano

AU - Patruno, Savino F A

AU - Perretti, Alessandro

AU - Poma, Gianluigi

AU - Sacchi, Paolo

AU - Zanaboni, Domenico

AU - Zaramella, Marco

PY - 2013

Y1 - 2013

N2 - AIM: To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used in a recently published meta-analysis. METHODS: This was a single center cross-sectional study. Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled. TE was carried out by using FibroScan™ (Echosens, Paris, France). Liver biopsy was performed on the same day as TE, as day case procedure. Fibrosis was staged according to the Metavir scoring system. The diagnostic performance of TE was assessed by using receiver operating characteristic (ROC) curves and the area under the ROC curve analysis. RESULTS: Two hundred and fifty-two patients met the inclusion criteria. Six (2%) patients were excluded due to unreliable TE measurements. Thus, 246 (171 men and 75 women) patients were analyzed. One hundred and ninety-five (79.3%) patients had chronic hepatitis C, 41 (16.7%) had chronic hepatitis B, and 10 (4.0%) were coinfected with human immunodeficiency virus. ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa for F ≥ 2; 7.9 kPa for F ≥ 3; 9.6 kPa for F = 4 in all patients (n = 246), and as high as 6.9 kPa for F ≥ 2; 7.3 kPa for F ≥ 3; 9.3 kPa for F = 4 in patients with hepatitis C (n = 195). Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2; 9.6 kPa for F ≥ 3; 12.2 kPa for F = 4 in all patients (n = 246), and as high as 7.0 kPa for F ≥ 2; 9.3 kPa for F ≥ 3; 12.3 kPa for F = 4 in patients with hepatitis C (n = 195). CONCLUSION: The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies.

AB - AIM: To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used in a recently published meta-analysis. METHODS: This was a single center cross-sectional study. Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled. TE was carried out by using FibroScan™ (Echosens, Paris, France). Liver biopsy was performed on the same day as TE, as day case procedure. Fibrosis was staged according to the Metavir scoring system. The diagnostic performance of TE was assessed by using receiver operating characteristic (ROC) curves and the area under the ROC curve analysis. RESULTS: Two hundred and fifty-two patients met the inclusion criteria. Six (2%) patients were excluded due to unreliable TE measurements. Thus, 246 (171 men and 75 women) patients were analyzed. One hundred and ninety-five (79.3%) patients had chronic hepatitis C, 41 (16.7%) had chronic hepatitis B, and 10 (4.0%) were coinfected with human immunodeficiency virus. ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa for F ≥ 2; 7.9 kPa for F ≥ 3; 9.6 kPa for F = 4 in all patients (n = 246), and as high as 6.9 kPa for F ≥ 2; 7.3 kPa for F ≥ 3; 9.3 kPa for F = 4 in patients with hepatitis C (n = 195). Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2; 9.6 kPa for F ≥ 3; 12.2 kPa for F = 4 in all patients (n = 246), and as high as 7.0 kPa for F ≥ 2; 9.3 kPa for F ≥ 3; 12.3 kPa for F = 4 in patients with hepatitis C (n = 195). CONCLUSION: The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies.

KW - Chronic viral hepatitis

KW - Elastography

KW - Fibroscan

KW - Hepatitis c

KW - Liver

KW - Liver biopsy

KW - Liver fibrosis

KW - Transient elastography

KW - Ultrasound

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U2 - 10.3748/wjg.v19.i1.49

DO - 10.3748/wjg.v19.i1.49

M3 - Article

C2 - 23326162

AN - SCOPUS:84873682565

VL - 19

SP - 49

EP - 56

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 1

ER -