Abstract
AIM: To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used in a recently published meta-analysis. METHODS: This was a single center cross-sectional study. Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled. TE was carried out by using FibroScan™ (Echosens, Paris, France). Liver biopsy was performed on the same day as TE, as day case procedure. Fibrosis was staged according to the Metavir scoring system. The diagnostic performance of TE was assessed by using receiver operating characteristic (ROC) curves and the area under the ROC curve analysis. RESULTS: Two hundred and fifty-two patients met the inclusion criteria. Six (2%) patients were excluded due to unreliable TE measurements. Thus, 246 (171 men and 75 women) patients were analyzed. One hundred and ninety-five (79.3%) patients had chronic hepatitis C, 41 (16.7%) had chronic hepatitis B, and 10 (4.0%) were coinfected with human immunodeficiency virus. ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa for F ≥ 2; 7.9 kPa for F ≥ 3; 9.6 kPa for F = 4 in all patients (n = 246), and as high as 6.9 kPa for F ≥ 2; 7.3 kPa for F ≥ 3; 9.3 kPa for F = 4 in patients with hepatitis C (n = 195). Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2; 9.6 kPa for F ≥ 3; 12.2 kPa for F = 4 in all patients (n = 246), and as high as 7.0 kPa for F ≥ 2; 9.3 kPa for F ≥ 3; 12.3 kPa for F = 4 in patients with hepatitis C (n = 195). CONCLUSION: The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies.
| Original language | English |
|---|---|
| Pages (from-to) | 49-56 |
| Number of pages | 8 |
| Journal | World Journal of Gastroenterology |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2013 |
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Keywords
- Chronic viral hepatitis
- Elastography
- Fibroscan
- Hepatitis c
- Liver
- Liver biopsy
- Liver fibrosis
- Transient elastography
- Ultrasound
ASJC Scopus subject areas
- Gastroenterology
Cite this
Performance of liver stiffness measurements by transient elastography in chronic hepatitis. / Ferraioli, Giovanna; Tinelli, Carmine; dal Bello, Barbara; Zicchetti, Mabel; Lissandrin, Raffaella; Filice, Gaetano; Filice, Carlo; Above, Elisabetta; Barbarini, Giorgio; Brunetti, Enrico; Calderon, Willy; Gregorio, Marta Di; Gulminetti, Roberto; Lanzarini, Paolo; Ludovisi, Serena; Maiocchi, Laura; Malfitano, Antonello; Michelone, Giuseppe; Minoli, Lorenzo; Mondelli, Mario; Novati, Stefano; Patruno, Savino F A; Perretti, Alessandro; Poma, Gianluigi; Sacchi, Paolo; Zanaboni, Domenico; Zaramella, Marco.
In: World Journal of Gastroenterology, Vol. 19, No. 1, 2013, p. 49-56.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Performance of liver stiffness measurements by transient elastography in chronic hepatitis
AU - Ferraioli, Giovanna
AU - Tinelli, Carmine
AU - dal Bello, Barbara
AU - Zicchetti, Mabel
AU - Lissandrin, Raffaella
AU - Filice, Gaetano
AU - Filice, Carlo
AU - Above, Elisabetta
AU - Barbarini, Giorgio
AU - Brunetti, Enrico
AU - Calderon, Willy
AU - Gregorio, Marta Di
AU - Gulminetti, Roberto
AU - Lanzarini, Paolo
AU - Ludovisi, Serena
AU - Maiocchi, Laura
AU - Malfitano, Antonello
AU - Michelone, Giuseppe
AU - Minoli, Lorenzo
AU - Mondelli, Mario
AU - Novati, Stefano
AU - Patruno, Savino F A
AU - Perretti, Alessandro
AU - Poma, Gianluigi
AU - Sacchi, Paolo
AU - Zanaboni, Domenico
AU - Zaramella, Marco
PY - 2013
Y1 - 2013
N2 - AIM: To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used in a recently published meta-analysis. METHODS: This was a single center cross-sectional study. Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled. TE was carried out by using FibroScan™ (Echosens, Paris, France). Liver biopsy was performed on the same day as TE, as day case procedure. Fibrosis was staged according to the Metavir scoring system. The diagnostic performance of TE was assessed by using receiver operating characteristic (ROC) curves and the area under the ROC curve analysis. RESULTS: Two hundred and fifty-two patients met the inclusion criteria. Six (2%) patients were excluded due to unreliable TE measurements. Thus, 246 (171 men and 75 women) patients were analyzed. One hundred and ninety-five (79.3%) patients had chronic hepatitis C, 41 (16.7%) had chronic hepatitis B, and 10 (4.0%) were coinfected with human immunodeficiency virus. ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa for F ≥ 2; 7.9 kPa for F ≥ 3; 9.6 kPa for F = 4 in all patients (n = 246), and as high as 6.9 kPa for F ≥ 2; 7.3 kPa for F ≥ 3; 9.3 kPa for F = 4 in patients with hepatitis C (n = 195). Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2; 9.6 kPa for F ≥ 3; 12.2 kPa for F = 4 in all patients (n = 246), and as high as 7.0 kPa for F ≥ 2; 9.3 kPa for F ≥ 3; 12.3 kPa for F = 4 in patients with hepatitis C (n = 195). CONCLUSION: The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies.
AB - AIM: To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used in a recently published meta-analysis. METHODS: This was a single center cross-sectional study. Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled. TE was carried out by using FibroScan™ (Echosens, Paris, France). Liver biopsy was performed on the same day as TE, as day case procedure. Fibrosis was staged according to the Metavir scoring system. The diagnostic performance of TE was assessed by using receiver operating characteristic (ROC) curves and the area under the ROC curve analysis. RESULTS: Two hundred and fifty-two patients met the inclusion criteria. Six (2%) patients were excluded due to unreliable TE measurements. Thus, 246 (171 men and 75 women) patients were analyzed. One hundred and ninety-five (79.3%) patients had chronic hepatitis C, 41 (16.7%) had chronic hepatitis B, and 10 (4.0%) were coinfected with human immunodeficiency virus. ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa for F ≥ 2; 7.9 kPa for F ≥ 3; 9.6 kPa for F = 4 in all patients (n = 246), and as high as 6.9 kPa for F ≥ 2; 7.3 kPa for F ≥ 3; 9.3 kPa for F = 4 in patients with hepatitis C (n = 195). Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2; 9.6 kPa for F ≥ 3; 12.2 kPa for F = 4 in all patients (n = 246), and as high as 7.0 kPa for F ≥ 2; 9.3 kPa for F ≥ 3; 12.3 kPa for F = 4 in patients with hepatitis C (n = 195). CONCLUSION: The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies.
KW - Chronic viral hepatitis
KW - Elastography
KW - Fibroscan
KW - Hepatitis c
KW - Liver
KW - Liver biopsy
KW - Liver fibrosis
KW - Transient elastography
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=84873682565&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873682565&partnerID=8YFLogxK
U2 - 10.3748/wjg.v19.i1.49
DO - 10.3748/wjg.v19.i1.49
M3 - Article
C2 - 23326162
AN - SCOPUS:84873682565
VL - 19
SP - 49
EP - 56
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 1
ER -