Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities

S.R. Johnson; R. Brinks; K.H. Costenbader; D. Daikh; M. Mosca; R. Ramsey-Goldman; J.S. Smolen; D. Wofsy; D.T. Boumpas; D.L. Kamen; D. Jayne; R. Cervera; N. Costedoat-Chalumeau; B. Diamond; D.D. Gladman; B. Hahn; F. Hiepe; Sø. Jacobsen; D. Khanna; K. Lerstrøm; E. Massarotti; J. McCune; G. Ruiz-Irastorza; J. Sanchez-Guerrero; M. Schneider; M. Urowitz; G. Bertsias; B.F. Hoyer; N. Leuchten; C. Tani; S.K. Tedeschi; Z. Touma; G. Schmajuk; B. Anic; F. Assan; T.M. Chan; A.E. Clarke; M.K. Crow; L. Czirják; A. Doria; W.B. Graninger; B. Halda-Kiss; S. Hasni; P.M. Izmirly; M. Jung; G. Kumánovics; X. Mariette; I. Padjen; J.M. Pego-Reigosa; J. Romero-Diaz; Í. Rúa-Figueroa; R. Seror; G.H. Stummvoll; Y. Tanaka; M.G. Tektonidou; C. Vasconcelos; E.M. Vital; D.J. Wallace; S. Yavuz; P.L. Meroni; M.J. Fritzler; R. Naden; T. Dörner; M. Aringer

doi:10.1136/annrheumdis-2020-217162

Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities

S.R. Johnson, R. Brinks, K.H. Costenbader, D. Daikh, M. Mosca, R. Ramsey-Goldman, J.S. Smolen, D. Wofsy, D.T. Boumpas, D.L. Kamen, D. Jayne, R. Cervera, N. Costedoat-Chalumeau, B. Diamond, D.D. Gladman, B. Hahn, F. Hiepe, Sø. Jacobsen, D. Khanna, K. LerstrømE. Massarotti, J. McCune, G. Ruiz-Irastorza, J. Sanchez-Guerrero, M. Schneider, M. Urowitz, G. Bertsias, B.F. Hoyer, N. Leuchten, C. Tani, S.K. Tedeschi, Z. Touma, G. Schmajuk, B. Anic, F. Assan, T.M. Chan, A.E. Clarke, M.K. Crow, L. Czirják, A. Doria, W.B. Graninger, B. Halda-Kiss, S. Hasni, P.M. Izmirly, M. Jung, G. Kumánovics, X. Mariette, I. Padjen, J.M. Pego-Reigosa, J. Romero-Diaz, Í. Rúa-Figueroa, R. Seror, G.H. Stummvoll, Y. Tanaka, M.G. Tektonidou, C. Vasconcelos, E.M. Vital, D.J. Wallace, S. Yavuz, P.L. Meroni, M.J. Fritzler, R. Naden, T. Dörner, M. Aringer

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 Classification Criteria for systemic lupus erythematosus (SLE) have been validated with high sensitivity and specificity. We evaluated the performance of the new criteria with regard to disease duration, sex and race/ethnicity, and compared its performance against the Systemic Lupus International Collaborating Clinics (SLICC) 2012 and ACR 1982/1997 criteria. Methods Twenty-one SLE centres from 16 countries submitted SLE cases and mimicking controls to form the validation cohort. The sensitivity and specificity of the EULAR/ACR 2019, SLICC 2012 and ACR 1982/1997 criteria were evaluated. Results The cohort consisted of female (n=1098), male (n=172), Asian (n=118), black (n=68), Hispanic (n=124) and white (n=941) patients; with an SLE duration of 1 to <3 years (n=196) and ≥5 years (n=879). Among patients with 1 to <3 years disease duration, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 81%). The EULAR/ACR criteria performed well in men (sensitivity 93%, specificity 96%) and women (sensitivity 97%, specificity 94%). Among women, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 83%) and better specificity than the SLICC criteria (94% vs 82%). Among white patients, the EULAR/ACR criteria had better sensitivity than the ACR criteria (95% vs 83%) and better specificity than the SLICC criteria (94% vs 83%). The EULAR/ACR criteria performed well among black patients (sensitivity of 98%, specificity 100%), and had better sensitivity than the ACR criteria among Hispanic patients (100% vs 86%) and Asian patients (97% vs 77%). Conclusions The EULAR/ACR 2019 criteria perform well among patients with early disease, men, women, white, black, Hispanic and Asian patients. These criteria have superior sensitivity than the ACR criteria and/or superior specificity than the SLICC criteria across many subgroups.

Original language	Italian
Pages (from-to)	1333-1339
Number of pages	7
Journal	Annals of the Rheumatic Diseases
Volume	79
Issue number	10
DOIs	https://doi.org/10.1136/annrheumdis-2020-217162
Publication status	Published - 2020

Access to Document

10.1136/annrheumdis-2020-217162

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090003541&doi=10.1136%2fannrheumdis-2020-217162&partnerID=40&md5=bda2b2878b55ccfa8c21e3f2f101dc95

Cite this

Johnson, S. R., Brinks, R., Costenbader, K. H., Daikh, D., Mosca, M., Ramsey-Goldman, R., Smolen, J. S., Wofsy, D., Boumpas, D. T., Kamen, D. L., Jayne, D., Cervera, R., Costedoat-Chalumeau, N., Diamond, B., Gladman, D. D., Hahn, B., Hiepe, F., Jacobsen, S., Khanna, D., ... Aringer, M. (2020). Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities. Annals of the Rheumatic Diseases, 79(10), 1333-1339. https://doi.org/10.1136/annrheumdis-2020-217162

Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities. / Johnson, S.R.; Brinks, R.; Costenbader, K.H.; Daikh, D.; Mosca, M.; Ramsey-Goldman, R.; Smolen, J.S.; Wofsy, D.; Boumpas, D.T.; Kamen, D.L.; Jayne, D.; Cervera, R.; Costedoat-Chalumeau, N.; Diamond, B.; Gladman, D.D.; Hahn, B.; Hiepe, F.; Jacobsen, Sø.; Khanna, D.; Lerstrøm, K.; Massarotti, E.; McCune, J.; Ruiz-Irastorza, G.; Sanchez-Guerrero, J.; Schneider, M.; Urowitz, M.; Bertsias, G.; Hoyer, B.F.; Leuchten, N.; Tani, C.; Tedeschi, S.K.; Touma, Z.; Schmajuk, G.; Anic, B.; Assan, F.; Chan, T.M.; Clarke, A.E.; Crow, M.K.; Czirják, L.; Doria, A.; Graninger, W.B.; Halda-Kiss, B.; Hasni, S.; Izmirly, P.M.; Jung, M.; Kumánovics, G.; Mariette, X.; Padjen, I.; Pego-Reigosa, J.M.; Romero-Diaz, J.; Rúa-Figueroa, Í.; Seror, R.; Stummvoll, G.H.; Tanaka, Y.; Tektonidou, M.G.; Vasconcelos, C.; Vital, E.M.; Wallace, D.J.; Yavuz, S.; Meroni, P.L.; Fritzler, M.J.; Naden, R.; Dörner, T.; Aringer, M.

In: Annals of the Rheumatic Diseases, Vol. 79, No. 10, 2020, p. 1333-1339.

Research output: Contribution to journal › Article › peer-review

Johnson, SR, Brinks, R, Costenbader, KH, Daikh, D, Mosca, M, Ramsey-Goldman, R, Smolen, JS, Wofsy, D, Boumpas, DT, Kamen, DL, Jayne, D, Cervera, R, Costedoat-Chalumeau, N, Diamond, B, Gladman, DD, Hahn, B, Hiepe, F, Jacobsen, S, Khanna, D, Lerstrøm, K, Massarotti, E, McCune, J, Ruiz-Irastorza, G, Sanchez-Guerrero, J, Schneider, M, Urowitz, M, Bertsias, G, Hoyer, BF, Leuchten, N, Tani, C, Tedeschi, SK, Touma, Z, Schmajuk, G, Anic, B, Assan, F, Chan, TM, Clarke, AE, Crow, MK, Czirják, L, Doria, A, Graninger, WB, Halda-Kiss, B, Hasni, S, Izmirly, PM, Jung, M, Kumánovics, G, Mariette, X, Padjen, I, Pego-Reigosa, JM, Romero-Diaz, J, Rúa-Figueroa, Í, Seror, R, Stummvoll, GH, Tanaka, Y, Tektonidou, MG, Vasconcelos, C, Vital, EM, Wallace, DJ, Yavuz, S, Meroni, PL, Fritzler, MJ, Naden, R, Dörner, T & Aringer, M 2020, 'Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities', Annals of the Rheumatic Diseases, vol. 79, no. 10, pp. 1333-1339. https://doi.org/10.1136/annrheumdis-2020-217162

Johnson, S.R. ; Brinks, R. ; Costenbader, K.H. ; Daikh, D. ; Mosca, M. ; Ramsey-Goldman, R. ; Smolen, J.S. ; Wofsy, D. ; Boumpas, D.T. ; Kamen, D.L. ; Jayne, D. ; Cervera, R. ; Costedoat-Chalumeau, N. ; Diamond, B. ; Gladman, D.D. ; Hahn, B. ; Hiepe, F. ; Jacobsen, Sø. ; Khanna, D. ; Lerstrøm, K. ; Massarotti, E. ; McCune, J. ; Ruiz-Irastorza, G. ; Sanchez-Guerrero, J. ; Schneider, M. ; Urowitz, M. ; Bertsias, G. ; Hoyer, B.F. ; Leuchten, N. ; Tani, C. ; Tedeschi, S.K. ; Touma, Z. ; Schmajuk, G. ; Anic, B. ; Assan, F. ; Chan, T.M. ; Clarke, A.E. ; Crow, M.K. ; Czirják, L. ; Doria, A. ; Graninger, W.B. ; Halda-Kiss, B. ; Hasni, S. ; Izmirly, P.M. ; Jung, M. ; Kumánovics, G. ; Mariette, X. ; Padjen, I. ; Pego-Reigosa, J.M. ; Romero-Diaz, J. ; Rúa-Figueroa, Í. ; Seror, R. ; Stummvoll, G.H. ; Tanaka, Y. ; Tektonidou, M.G. ; Vasconcelos, C. ; Vital, E.M. ; Wallace, D.J. ; Yavuz, S. ; Meroni, P.L. ; Fritzler, M.J. ; Naden, R. ; Dörner, T. ; Aringer, M. / Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities. In: Annals of the Rheumatic Diseases. 2020 ; Vol. 79, No. 10. pp. 1333-1339.

@article{5fb8a5bab69c499386b391f08a851840,

title = "Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities",

abstract = "Objectives The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 Classification Criteria for systemic lupus erythematosus (SLE) have been validated with high sensitivity and specificity. We evaluated the performance of the new criteria with regard to disease duration, sex and race/ethnicity, and compared its performance against the Systemic Lupus International Collaborating Clinics (SLICC) 2012 and ACR 1982/1997 criteria. Methods Twenty-one SLE centres from 16 countries submitted SLE cases and mimicking controls to form the validation cohort. The sensitivity and specificity of the EULAR/ACR 2019, SLICC 2012 and ACR 1982/1997 criteria were evaluated. Results The cohort consisted of female (n=1098), male (n=172), Asian (n=118), black (n=68), Hispanic (n=124) and white (n=941) patients; with an SLE duration of 1 to <3 years (n=196) and ≥5 years (n=879). Among patients with 1 to <3 years disease duration, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 81%). The EULAR/ACR criteria performed well in men (sensitivity 93%, specificity 96%) and women (sensitivity 97%, specificity 94%). Among women, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 83%) and better specificity than the SLICC criteria (94% vs 82%). Among white patients, the EULAR/ACR criteria had better sensitivity than the ACR criteria (95% vs 83%) and better specificity than the SLICC criteria (94% vs 83%). The EULAR/ACR criteria performed well among black patients (sensitivity of 98%, specificity 100%), and had better sensitivity than the ACR criteria among Hispanic patients (100% vs 86%) and Asian patients (97% vs 77%). Conclusions The EULAR/ACR 2019 criteria perform well among patients with early disease, men, women, white, black, Hispanic and Asian patients. These criteria have superior sensitivity than the ACR criteria and/or superior specificity than the SLICC criteria across many subgroups. ",

author = "S.R. Johnson and R. Brinks and K.H. Costenbader and D. Daikh and M. Mosca and R. Ramsey-Goldman and J.S. Smolen and D. Wofsy and D.T. Boumpas and D.L. Kamen and D. Jayne and R. Cervera and N. Costedoat-Chalumeau and B. Diamond and D.D. Gladman and B. Hahn and F. Hiepe and S{\o}. Jacobsen and D. Khanna and K. Lerstr{\o}m and E. Massarotti and J. McCune and G. Ruiz-Irastorza and J. Sanchez-Guerrero and M. Schneider and M. Urowitz and G. Bertsias and B.F. Hoyer and N. Leuchten and C. Tani and S.K. Tedeschi and Z. Touma and G. Schmajuk and B. Anic and F. Assan and T.M. Chan and A.E. Clarke and M.K. Crow and L. Czirj{\'a}k and A. Doria and W.B. Graninger and B. Halda-Kiss and S. Hasni and P.M. Izmirly and M. Jung and G. Kum{\'a}novics and X. Mariette and I. Padjen and J.M. Pego-Reigosa and J. Romero-Diaz and {\'I}. R{\'u}a-Figueroa and R. Seror and G.H. Stummvoll and Y. Tanaka and M.G. Tektonidou and C. Vasconcelos and E.M. Vital and D.J. Wallace and S. Yavuz and P.L. Meroni and M.J. Fritzler and R. Naden and T. D{\"o}rner and M. Aringer",

note = "Cited By :5 Export Date: 15 February 2021",

year = "2020",

doi = "10.1136/annrheumdis-2020-217162",

language = "Italian",

volume = "79",

pages = "1333--1339",

journal = "Annals of the Rheumatic Diseases",

issn = "0003-4967",

publisher = "BMJ Publishing Group",

number = "10",

}

TY - JOUR

T1 - Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities

AU - Johnson, S.R.

AU - Brinks, R.

AU - Costenbader, K.H.

AU - Daikh, D.

AU - Mosca, M.

AU - Ramsey-Goldman, R.

AU - Smolen, J.S.

AU - Wofsy, D.

AU - Boumpas, D.T.

AU - Kamen, D.L.

AU - Jayne, D.

AU - Cervera, R.

AU - Costedoat-Chalumeau, N.

AU - Diamond, B.

AU - Gladman, D.D.

AU - Hahn, B.

AU - Hiepe, F.

AU - Jacobsen, Sø.

AU - Khanna, D.

AU - Lerstrøm, K.

AU - Massarotti, E.

AU - McCune, J.

AU - Ruiz-Irastorza, G.

AU - Sanchez-Guerrero, J.

AU - Schneider, M.

AU - Urowitz, M.

AU - Bertsias, G.

AU - Hoyer, B.F.

AU - Leuchten, N.

AU - Tani, C.

AU - Tedeschi, S.K.

AU - Touma, Z.

AU - Schmajuk, G.

AU - Anic, B.

AU - Assan, F.

AU - Chan, T.M.

AU - Clarke, A.E.

AU - Crow, M.K.

AU - Czirják, L.

AU - Doria, A.

AU - Graninger, W.B.

AU - Halda-Kiss, B.

AU - Hasni, S.

AU - Izmirly, P.M.

AU - Jung, M.

AU - Kumánovics, G.

AU - Mariette, X.

AU - Padjen, I.

AU - Pego-Reigosa, J.M.

AU - Romero-Diaz, J.

AU - Rúa-Figueroa, Í.

AU - Seror, R.

AU - Stummvoll, G.H.

AU - Tanaka, Y.

AU - Tektonidou, M.G.

AU - Vasconcelos, C.

AU - Vital, E.M.

AU - Wallace, D.J.

AU - Yavuz, S.

AU - Meroni, P.L.

AU - Fritzler, M.J.

AU - Naden, R.

AU - Dörner, T.

AU - Aringer, M.

N1 - Cited By :5 Export Date: 15 February 2021

PY - 2020

Y1 - 2020

N2 - Objectives The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 Classification Criteria for systemic lupus erythematosus (SLE) have been validated with high sensitivity and specificity. We evaluated the performance of the new criteria with regard to disease duration, sex and race/ethnicity, and compared its performance against the Systemic Lupus International Collaborating Clinics (SLICC) 2012 and ACR 1982/1997 criteria. Methods Twenty-one SLE centres from 16 countries submitted SLE cases and mimicking controls to form the validation cohort. The sensitivity and specificity of the EULAR/ACR 2019, SLICC 2012 and ACR 1982/1997 criteria were evaluated. Results The cohort consisted of female (n=1098), male (n=172), Asian (n=118), black (n=68), Hispanic (n=124) and white (n=941) patients; with an SLE duration of 1 to <3 years (n=196) and ≥5 years (n=879). Among patients with 1 to <3 years disease duration, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 81%). The EULAR/ACR criteria performed well in men (sensitivity 93%, specificity 96%) and women (sensitivity 97%, specificity 94%). Among women, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 83%) and better specificity than the SLICC criteria (94% vs 82%). Among white patients, the EULAR/ACR criteria had better sensitivity than the ACR criteria (95% vs 83%) and better specificity than the SLICC criteria (94% vs 83%). The EULAR/ACR criteria performed well among black patients (sensitivity of 98%, specificity 100%), and had better sensitivity than the ACR criteria among Hispanic patients (100% vs 86%) and Asian patients (97% vs 77%). Conclusions The EULAR/ACR 2019 criteria perform well among patients with early disease, men, women, white, black, Hispanic and Asian patients. These criteria have superior sensitivity than the ACR criteria and/or superior specificity than the SLICC criteria across many subgroups.

AB - Objectives The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 Classification Criteria for systemic lupus erythematosus (SLE) have been validated with high sensitivity and specificity. We evaluated the performance of the new criteria with regard to disease duration, sex and race/ethnicity, and compared its performance against the Systemic Lupus International Collaborating Clinics (SLICC) 2012 and ACR 1982/1997 criteria. Methods Twenty-one SLE centres from 16 countries submitted SLE cases and mimicking controls to form the validation cohort. The sensitivity and specificity of the EULAR/ACR 2019, SLICC 2012 and ACR 1982/1997 criteria were evaluated. Results The cohort consisted of female (n=1098), male (n=172), Asian (n=118), black (n=68), Hispanic (n=124) and white (n=941) patients; with an SLE duration of 1 to <3 years (n=196) and ≥5 years (n=879). Among patients with 1 to <3 years disease duration, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 81%). The EULAR/ACR criteria performed well in men (sensitivity 93%, specificity 96%) and women (sensitivity 97%, specificity 94%). Among women, the EULAR/ACR criteria had better sensitivity than the ACR criteria (97% vs 83%) and better specificity than the SLICC criteria (94% vs 82%). Among white patients, the EULAR/ACR criteria had better sensitivity than the ACR criteria (95% vs 83%) and better specificity than the SLICC criteria (94% vs 83%). The EULAR/ACR criteria performed well among black patients (sensitivity of 98%, specificity 100%), and had better sensitivity than the ACR criteria among Hispanic patients (100% vs 86%) and Asian patients (97% vs 77%). Conclusions The EULAR/ACR 2019 criteria perform well among patients with early disease, men, women, white, black, Hispanic and Asian patients. These criteria have superior sensitivity than the ACR criteria and/or superior specificity than the SLICC criteria across many subgroups.

U2 - 10.1136/annrheumdis-2020-217162

DO - 10.1136/annrheumdis-2020-217162

M3 - Articolo

VL - 79

SP - 1333

EP - 1339

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 10

ER -