Performance of the Multidimensional Geriatric Assessment and Multidimensional Prognostic Index in predicting negative outcomes in older adults with cancer

V. Giantin, C. Falci, E. De Luca, E. Valentini, M. Iasevoli, P. Siviero, S. Maggi, B. Martella, G. Crepaldi, S. Monfardini, E. Manzato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The Multidimensional Geriatric Assessment (MGA) is currently used for assessing geriatric oncological patients, but a new prognostic index - the Multidimensional Prognostic Index (MPI) - has a demonstrated prognostic value in cancer patients too. The present work was designed to compare the MPI and MGA as predictors of 12-month mortality. 160 patients ≥70 years old with locally-advanced or metastatic solid cancers consecutively joining our Geriatric Oncology Program were administered a Comprehensive Geriatric Assessment to calculate their MGA and MPI scores. Settings: Geriatric Clinic, Geriatric Surgery Clinic, Medical Oncology Unit, Padova Hospital, Italy. Using Cohen's Kappa coefficient, there was a poor concordance between the MPI and MGA. Severe MPI being associated with a higher mortality risk than Frail in the MGA. The ROC curves indicated that the MPI had a greater discriminatory power for 12-month mortality than the MGA. In our population of elderly cancer patients, the MPI performed better than the MGA in predicting mortality. Further evidence from larger prospective trials is needed to establish whether other geriatric scales, such as the GDS and CIRS-SI, could enhance the value of prognostic indexes applied to elderly cancer patients.

Original languageEnglish
JournalEuropean Journal of Cancer Care
Early online dateOct 10 2016
DOIs
Publication statusE-pub ahead of print - Oct 10 2016

Fingerprint

Geriatric Assessment
Geriatrics
Neoplasms
Mortality
Hospital Units
Medical Oncology
ROC Curve
Italy

Keywords

  • Multidimensional Geriatric Assessment
  • Multidimensional Prognostic Index

ASJC Scopus subject areas

  • Oncology

Cite this

Performance of the Multidimensional Geriatric Assessment and Multidimensional Prognostic Index in predicting negative outcomes in older adults with cancer. / Giantin, V.; Falci, C.; De Luca, E.; Valentini, E.; Iasevoli, M.; Siviero, P.; Maggi, S.; Martella, B.; Crepaldi, G.; Monfardini, S.; Manzato, E.

In: European Journal of Cancer Care, 10.10.2016.

Research output: Contribution to journalArticle

Giantin, V. ; Falci, C. ; De Luca, E. ; Valentini, E. ; Iasevoli, M. ; Siviero, P. ; Maggi, S. ; Martella, B. ; Crepaldi, G. ; Monfardini, S. ; Manzato, E. / Performance of the Multidimensional Geriatric Assessment and Multidimensional Prognostic Index in predicting negative outcomes in older adults with cancer. In: European Journal of Cancer Care. 2016.
@article{1ff35e79377a418e8231986dfc23da74,
title = "Performance of the Multidimensional Geriatric Assessment and Multidimensional Prognostic Index in predicting negative outcomes in older adults with cancer",
abstract = "The Multidimensional Geriatric Assessment (MGA) is currently used for assessing geriatric oncological patients, but a new prognostic index - the Multidimensional Prognostic Index (MPI) - has a demonstrated prognostic value in cancer patients too. The present work was designed to compare the MPI and MGA as predictors of 12-month mortality. 160 patients ≥70 years old with locally-advanced or metastatic solid cancers consecutively joining our Geriatric Oncology Program were administered a Comprehensive Geriatric Assessment to calculate their MGA and MPI scores. Settings: Geriatric Clinic, Geriatric Surgery Clinic, Medical Oncology Unit, Padova Hospital, Italy. Using Cohen's Kappa coefficient, there was a poor concordance between the MPI and MGA. Severe MPI being associated with a higher mortality risk than Frail in the MGA. The ROC curves indicated that the MPI had a greater discriminatory power for 12-month mortality than the MGA. In our population of elderly cancer patients, the MPI performed better than the MGA in predicting mortality. Further evidence from larger prospective trials is needed to establish whether other geriatric scales, such as the GDS and CIRS-SI, could enhance the value of prognostic indexes applied to elderly cancer patients.",
keywords = "Multidimensional Geriatric Assessment, Multidimensional Prognostic Index",
author = "V. Giantin and C. Falci and {De Luca}, E. and E. Valentini and M. Iasevoli and P. Siviero and S. Maggi and B. Martella and G. Crepaldi and S. Monfardini and E. Manzato",
year = "2016",
month = "10",
day = "10",
doi = "10.1111/ecc.12585",
language = "English",
journal = "European Journal of Cancer Care",
issn = "0961-5423",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Performance of the Multidimensional Geriatric Assessment and Multidimensional Prognostic Index in predicting negative outcomes in older adults with cancer

AU - Giantin, V.

AU - Falci, C.

AU - De Luca, E.

AU - Valentini, E.

AU - Iasevoli, M.

AU - Siviero, P.

AU - Maggi, S.

AU - Martella, B.

AU - Crepaldi, G.

AU - Monfardini, S.

AU - Manzato, E.

PY - 2016/10/10

Y1 - 2016/10/10

N2 - The Multidimensional Geriatric Assessment (MGA) is currently used for assessing geriatric oncological patients, but a new prognostic index - the Multidimensional Prognostic Index (MPI) - has a demonstrated prognostic value in cancer patients too. The present work was designed to compare the MPI and MGA as predictors of 12-month mortality. 160 patients ≥70 years old with locally-advanced or metastatic solid cancers consecutively joining our Geriatric Oncology Program were administered a Comprehensive Geriatric Assessment to calculate their MGA and MPI scores. Settings: Geriatric Clinic, Geriatric Surgery Clinic, Medical Oncology Unit, Padova Hospital, Italy. Using Cohen's Kappa coefficient, there was a poor concordance between the MPI and MGA. Severe MPI being associated with a higher mortality risk than Frail in the MGA. The ROC curves indicated that the MPI had a greater discriminatory power for 12-month mortality than the MGA. In our population of elderly cancer patients, the MPI performed better than the MGA in predicting mortality. Further evidence from larger prospective trials is needed to establish whether other geriatric scales, such as the GDS and CIRS-SI, could enhance the value of prognostic indexes applied to elderly cancer patients.

AB - The Multidimensional Geriatric Assessment (MGA) is currently used for assessing geriatric oncological patients, but a new prognostic index - the Multidimensional Prognostic Index (MPI) - has a demonstrated prognostic value in cancer patients too. The present work was designed to compare the MPI and MGA as predictors of 12-month mortality. 160 patients ≥70 years old with locally-advanced or metastatic solid cancers consecutively joining our Geriatric Oncology Program were administered a Comprehensive Geriatric Assessment to calculate their MGA and MPI scores. Settings: Geriatric Clinic, Geriatric Surgery Clinic, Medical Oncology Unit, Padova Hospital, Italy. Using Cohen's Kappa coefficient, there was a poor concordance between the MPI and MGA. Severe MPI being associated with a higher mortality risk than Frail in the MGA. The ROC curves indicated that the MPI had a greater discriminatory power for 12-month mortality than the MGA. In our population of elderly cancer patients, the MPI performed better than the MGA in predicting mortality. Further evidence from larger prospective trials is needed to establish whether other geriatric scales, such as the GDS and CIRS-SI, could enhance the value of prognostic indexes applied to elderly cancer patients.

KW - Multidimensional Geriatric Assessment

KW - Multidimensional Prognostic Index

UR - http://www.scopus.com/inward/record.url?scp=84995953635&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84995953635&partnerID=8YFLogxK

U2 - 10.1111/ecc.12585

DO - 10.1111/ecc.12585

M3 - Article

JO - European Journal of Cancer Care

JF - European Journal of Cancer Care

SN - 0961-5423

ER -