Perfusion computed tomography for monitoring induction chemotherapy in patients with squamous cell carcinoma of the upper aerodigestive tract: Correlation between changes in tumor perfusion and tumor volume

Giuseppe Petralia, Lorenzo Preda, Gioacchino Giugliano, Barbara A. Jereczek-Fossa, Andrea Rocca, Gabriele D'Andrea, Nagaraj Setty Holalkere, Fausto Chiesa, Massimo Bellomi

Research output: Contribution to journalArticle

Abstract

Objective:: The aim of this study was to assess the potential of perfusion computed tomography (CTp) for monitoring induction chemotherapy in patients with squamous cell carcinoma (SCCA) of the upper aerodigestive tract. Materials and Methods:: Twenty-five patients with advanced SCCA underwent CTp and volumetric CT before and after induction chemotherapy. Perfusion CT parameters were calculated in the tumor, normal tissue, and muscles and correlated with tumor volume. Results:: The blood flow (BF), blood volume (BV), and permeability surface were significantly higher, and the mean transit time was significantly lower in the tumor than in the normal tissue. The tumor BF and BV significantly decreased, and the mean transit time significantly increased after the therapy; decrease in BF and BV correlated with tumor volume reduction after chemotherapy. The baseline tumor BV was significantly lower in nonresponders compared with that in responders. Conclusions:: In patients with SCCA, CTp showed potential for monitoring induction chemotherapy, reduction in tumor BF and BV correlated with reduction of tumor volume after chemotherapy, and baseline tumor BV may predict response to chemotherapy.

Original languageEnglish
Pages (from-to)552-559
Number of pages8
JournalJournal of Computer Assisted Tomography
Volume33
Issue number4
DOIs
Publication statusPublished - Jul 2009

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Keywords

  • Chemotherapy
  • Monitoring
  • Perfusion CT
  • Tumor volume
  • Upper aerodigestive tract

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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