Perfusion-weighted dynamic susceptibility (DSC) MRI: Basal ganglia hemodynamic changes after apomorphine in Parkinson's disease

L. Brusa, A. Bassi, M. Pierantozzi, F. Gaudiello, S. Frasca, R. Floris, P. Stanzione

Research output: Contribution to journalArticlepeer-review

Abstract

Relative regional blood flow of basal ganglia wa studied by means of perfusion-weighted dynamic susceptibility (DSC) MRI. Parkinson's disease (PD) patients showed a significant inter-hemispheric asymmetry due to a higher perfusion in the more affected side, while normal subjects did not. PD exhibited an abnormal "asymmetry index" in the measured nuclei. A second DSC-MRI examination performed after subcutaneous apomorphine administration did not show any significant asymmetry in PD patients. DSC-MRI of basal ganglia confirms the asymmtery observed in PET studies of PD patients, suggesting that this method is a promising and low-cost technique in neurodegenerative diseases.

Original languageEnglish
JournalNeurological Sciences
Volume23
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Sep 2002

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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