TY - JOUR
T1 - Perfusional and metabolic effects of nisoldipine as shown by positron emission tomography after acute myocardial infarction
AU - Brunelli, Claudio
AU - Parodi, Oberdan
AU - Sambuceti, Gianmario
AU - Corsiglia, Luca
AU - Rosa, Gian M.
AU - Giorgetti, Assuero
AU - Bezante, Gian P.
AU - Nista, Nicola
AU - Caponnetto, Salvatore
PY - 1995/4/27
Y1 - 1995/4/27
N2 - After myocardial infarction, regional dysfunction can occur in viable myocardial regions because of the presence of baseline hypoperfusion. Recent evidence suggests that these areas may maintain a residual perfusion reserve. The aim of the present study was to evaluate whether oral nisoldipine can increase regional myocardial blood flow (MBF) in dyssynergic but viable myocardium after myocardial infarction. Patients with isolated left anterior descending coronary stenosis were studied 1 month after the first myocardial infarction. Patients underwent [18F]fluorodeoxyglucose imaging, and MBF was measured, using positron emission tomography and [13N]ammonia, at baseline and following dobutamine administration (10 μg/kg/min over 5 minutes). MBF measurements were repeated 24 hours after nisoldipine (10 mg twice daily). Preliminary results suggest that necrotic areas showed the largest reduction in baseline MBF. Dyssynergicviable regions showed a reduced resting MBF but maintained a residual perfusion reserve in response to inotropic stimulation. Thus, nisoldipine selectively improved basal perfusion in dyssynergicviable myocardium.
AB - After myocardial infarction, regional dysfunction can occur in viable myocardial regions because of the presence of baseline hypoperfusion. Recent evidence suggests that these areas may maintain a residual perfusion reserve. The aim of the present study was to evaluate whether oral nisoldipine can increase regional myocardial blood flow (MBF) in dyssynergic but viable myocardium after myocardial infarction. Patients with isolated left anterior descending coronary stenosis were studied 1 month after the first myocardial infarction. Patients underwent [18F]fluorodeoxyglucose imaging, and MBF was measured, using positron emission tomography and [13N]ammonia, at baseline and following dobutamine administration (10 μg/kg/min over 5 minutes). MBF measurements were repeated 24 hours after nisoldipine (10 mg twice daily). Preliminary results suggest that necrotic areas showed the largest reduction in baseline MBF. Dyssynergicviable regions showed a reduced resting MBF but maintained a residual perfusion reserve in response to inotropic stimulation. Thus, nisoldipine selectively improved basal perfusion in dyssynergicviable myocardium.
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U2 - 10.1016/S0002-9149(99)80445-7
DO - 10.1016/S0002-9149(99)80445-7
M3 - Article
C2 - 7726121
AN - SCOPUS:0028904015
VL - 75
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 13 SUPPL. 1
ER -