Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention

Beatrice Vignoli, Giulia Battistini, Riccardo Melani, Robert Blum, Spartaco Santi, Nicoletta Berardi, Marco Canossa

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Glial cells respond to neuronal activation and release neuroactive molecules (termed “gliotransmitters”) that can affect synaptic activity and modulate plasticity. In this study, we used molecular genetic tools, ultra-structural microscopy, and electrophysiology to assess the role of brain-derived neurotrophic factor (BDNF) on cortical gliotransmission in vivo. We find that glial cells recycle BDNF that was previously secreted by neurons as pro-neurotrophin following long-term potentiation (LTP)-inducing electrical stimulation. Upon BDNF glial recycling, we observed tight, temporal, highly localized TrkB phosphorylation on adjacent neurons, a process required to sustain LTP. Engagement of BDNF recycling by astrocytes represents a novel mechanism by which cortical synapses can expand BDNF action and provide synaptic changes that are relevant for the acquisition of new memories. Accordingly, mice deficient in BDNF glial recycling fail to recognize familiar from novel objects, indicating a physiological requirement for this process in memory consolidation.

Original languageEnglish
Pages (from-to)873-887
Number of pages15
JournalNeuron
Volume92
Issue number4
DOIs
Publication statusPublished - Nov 23 2016

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Long-Term Memory
Long-Term Potentiation
Brain-Derived Neurotrophic Factor
Neuroglia
Neurons
Electrophysiology
Nerve Growth Factors
Recycling
Astrocytes
Synapses
Electric Stimulation
Retention (Psychology)
Molecular Biology
Microscopy
Phosphorylation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vignoli, B., Battistini, G., Melani, R., Blum, R., Santi, S., Berardi, N., & Canossa, M. (2016). Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention. Neuron, 92(4), 873-887. https://doi.org/10.1016/j.neuron.2016.09.031

Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention. / Vignoli, Beatrice; Battistini, Giulia; Melani, Riccardo; Blum, Robert; Santi, Spartaco; Berardi, Nicoletta; Canossa, Marco.

In: Neuron, Vol. 92, No. 4, 23.11.2016, p. 873-887.

Research output: Contribution to journalArticle

Vignoli, B, Battistini, G, Melani, R, Blum, R, Santi, S, Berardi, N & Canossa, M 2016, 'Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention', Neuron, vol. 92, no. 4, pp. 873-887. https://doi.org/10.1016/j.neuron.2016.09.031
Vignoli, Beatrice ; Battistini, Giulia ; Melani, Riccardo ; Blum, Robert ; Santi, Spartaco ; Berardi, Nicoletta ; Canossa, Marco. / Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention. In: Neuron. 2016 ; Vol. 92, No. 4. pp. 873-887.
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