Peri-tumoral inflammatory cell infiltration in OSCC: A reliable marker of local recurrence and prognosis? An investigation using artificial neural networks

G. Campisi, F. Calvino, F. Carinci, D. Matranga, M. Carella, M. Mazzotta, C. Rubini, V. Panzarella, A. Santarelli, S. Fedele, L. Lo Muzio

Research output: Contribution to journalArticlepeer-review

Abstract

The presence of inflammatory reaction in peri-tumoural connective tissue is generally considered as a defense mechanism against cancer, but inflammation tissue in malignant transformation and early steps of oncogenesis has been recently proven to play a supporting and aggravating role in some carcinomas. Aims of this retrospective study were to evaluate in OSCCs the independent association of peri-tumoral inflammatory infiltrate (PTI) with local recurrence (LR) or survival outcome, and to verify whether PTI can be considered a marker of prognosis. Data from 211 cases of OSCC, only surgically treated between 1990 and 2000, were collected and retrospectively analyzed for PTI and the event LR (5 yrs follow-up at least) by means of univariate-multivariate and neural networks analyses. Patients (mean age 65.3 ± 12.4 yrs, M/F = 2.98) showed presence of PTI in 68.2% (144/211): (+) in 27.0%, (++) in 25.6%, (+++) 15.6%; PTI was found reduced in 24.7% of cases and absent in 7.1%. In overall PTI+ve group (n=144), 66 were TNM Stage I, 33 Stage II, 45 Stage III, none Stage IV. LR (mean 6 ± 4 months) was present in 87/211 (41.2%) patients, of which 43/144 (29.8%) in OSCCs with PTI [23 (+),. 13 (++) and 7 (+++)] vs. 44/67 (65.7%) in OSCC with PTI -/+ or PTI-ve ones. By univariate analysis, PTI+ve cases showed a significant lower risk to have LR (p

Original languageEnglish
Pages (from-to)113-120
Number of pages8
JournalInternational Journal of Immunopathology and Pharmacology
Volume24
DOIs
Publication statusPublished - Apr 1 2011

Keywords

  • marker
  • oral carcinoma
  • recurrence
  • survival rate

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'Peri-tumoral inflammatory cell infiltration in OSCC: A reliable marker of local recurrence and prognosis? An investigation using artificial neural networks'. Together they form a unique fingerprint.

Cite this