Perinatal brain damage in children. Neuroplasticity, early intervention, and molecular mechanisms of recovery

Research output: Contribution to journalArticlepeer-review

Abstract

During the perinatal period, the nervous system is very vulnerable to insult. At this time, the brain undergoes fast and complex maturational processes such as synaptogenesis, arborization, and apoptosis, and the response to the insult is highly dependent on its exact timing. There is evidence that some of the neuroplastic mechanisms adopted by the young brain after damage are unavailable at a later stage of maturation. This applies, for example, to the reorganization of language, the sensorimotor system, or the visual system. Expanding our knowledge on these mechanisms could help the development of early therapeutic interventions aimed at supporting and enhancing functional reorganization at a time of greatest potential brain plasticity.

Original languageEnglish
Pages (from-to)139-154
Number of pages16
JournalProgress in Brain Research
Volume189
DOIs
Publication statusPublished - 2011

Keywords

  • Brain plasticity
  • Congenital lesion
  • Environmental enrichment
  • Newborn
  • Reorganization

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Perinatal brain damage in children. Neuroplasticity, early intervention, and molecular mechanisms of recovery'. Together they form a unique fingerprint.

Cite this