Perinatal development of styrene monooxygenase and epoxide hydrolase in rat liver microsomes and nuclei

M. Romano, G. Gazzotti, V. Clos, B. M. Assael, R. Maffei Facino, M. Salmona

Research output: Contribution to journalArticle

Abstract

Nuclear enzymes were found to develop earlier than the corresponding microsomal activities. In fact styrene monooxygenase enzymatic activity at 18 days gestational age reached about half the values of adult animals, whereas fetal microsomal activity was only about 1 20 the adult level at the same age. In microsomes and nuclei the ontogenic development of epoxide hydrolase is slightly slower than styrene monooxygenase. This suggests that fetuses and newborn animals are exposed to higher risk of accumulation of styrene-7,8-oxide, a toxic and possibly teratogenic product of styrene monooxygenase.

Original languageEnglish
Pages (from-to)213-222
Number of pages10
JournalChemico-Biological Interactions
Volume47
Issue number2
DOIs
Publication statusPublished - 1983

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Keywords

  • Nuclear metabolism
  • Nuclei
  • Perinatal metabolism
  • Styrene
  • Styrene-7,8-oxide

ASJC Scopus subject areas

  • Toxicology

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