Perinatal exposure to morphine: Reactive changes in the brain after 6-hydroxydopamine

Alfredo Gorio, Letizia Vergani, Maria Luisa Malosio, Elena Lesma, Anna Maria Di Giulio

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of neonatal 6-hydroxydopamine treatment on the brain of control rats and of rats perinatally exposed to morphine were examined. Noradrenaline levels were increased in the pons-medulla, mesencephalon and caudate of 8-week-old control rats lesioned with neonatal 6-hydroxydopamine; perinatal morphine treatment prevented such an increase. In the caudate, there was a loss of dopamine and an increase of serotonin following the neurotoxic lesion; exposure to perinatal morphine prevented the serotonin increase. Brain expression of synapsin I mRNA was particularly abundant in cerebral cortex, hippocampus, dentate gyrus and olfactory bulb. In perinatal morphine-treated rats, the expression of synapsin I mRNA was significantly reduced; interestingly, the neonatal treatment with 6-hydroxydopamine normalized its expression. Therefore, brain-reactive neurochemical changes triggered by 6-hydroxydopamine were suppressed by perinatal morphine exposure whereas the association of morphine exposure and 6-hydroxydopamine lesion promoted the normal mRNA expression of the synaptic marker synapsin I.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalEuropean Journal of Pharmacology
Volume303
Issue number1-2
DOIs
Publication statusPublished - May 6 1996

Fingerprint

Oxidopamine
Morphine
Synapsins
Brain
Messenger RNA
Serotonin
Pons
Olfactory Bulb
Dentate Gyrus
Mesencephalon
Cerebral Cortex
Hippocampus
Dopamine
Norepinephrine

Keywords

  • Neuronal plasticity
  • Opiate receptor
  • Pruning effect
  • Synapsin I

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Perinatal exposure to morphine : Reactive changes in the brain after 6-hydroxydopamine. / Gorio, Alfredo; Vergani, Letizia; Malosio, Maria Luisa; Lesma, Elena; Di Giulio, Anna Maria.

In: European Journal of Pharmacology, Vol. 303, No. 1-2, 06.05.1996, p. 21-26.

Research output: Contribution to journalArticle

Gorio, Alfredo ; Vergani, Letizia ; Malosio, Maria Luisa ; Lesma, Elena ; Di Giulio, Anna Maria. / Perinatal exposure to morphine : Reactive changes in the brain after 6-hydroxydopamine. In: European Journal of Pharmacology. 1996 ; Vol. 303, No. 1-2. pp. 21-26.
@article{4a387f70600d44628bfa62ab203d5751,
title = "Perinatal exposure to morphine: Reactive changes in the brain after 6-hydroxydopamine",
abstract = "The effects of neonatal 6-hydroxydopamine treatment on the brain of control rats and of rats perinatally exposed to morphine were examined. Noradrenaline levels were increased in the pons-medulla, mesencephalon and caudate of 8-week-old control rats lesioned with neonatal 6-hydroxydopamine; perinatal morphine treatment prevented such an increase. In the caudate, there was a loss of dopamine and an increase of serotonin following the neurotoxic lesion; exposure to perinatal morphine prevented the serotonin increase. Brain expression of synapsin I mRNA was particularly abundant in cerebral cortex, hippocampus, dentate gyrus and olfactory bulb. In perinatal morphine-treated rats, the expression of synapsin I mRNA was significantly reduced; interestingly, the neonatal treatment with 6-hydroxydopamine normalized its expression. Therefore, brain-reactive neurochemical changes triggered by 6-hydroxydopamine were suppressed by perinatal morphine exposure whereas the association of morphine exposure and 6-hydroxydopamine lesion promoted the normal mRNA expression of the synaptic marker synapsin I.",
keywords = "Neuronal plasticity, Opiate receptor, Pruning effect, Synapsin I",
author = "Alfredo Gorio and Letizia Vergani and Malosio, {Maria Luisa} and Elena Lesma and {Di Giulio}, {Anna Maria}",
year = "1996",
month = "5",
day = "6",
doi = "10.1016/0014-2999(96)00054-4",
language = "English",
volume = "303",
pages = "21--26",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Perinatal exposure to morphine

T2 - Reactive changes in the brain after 6-hydroxydopamine

AU - Gorio, Alfredo

AU - Vergani, Letizia

AU - Malosio, Maria Luisa

AU - Lesma, Elena

AU - Di Giulio, Anna Maria

PY - 1996/5/6

Y1 - 1996/5/6

N2 - The effects of neonatal 6-hydroxydopamine treatment on the brain of control rats and of rats perinatally exposed to morphine were examined. Noradrenaline levels were increased in the pons-medulla, mesencephalon and caudate of 8-week-old control rats lesioned with neonatal 6-hydroxydopamine; perinatal morphine treatment prevented such an increase. In the caudate, there was a loss of dopamine and an increase of serotonin following the neurotoxic lesion; exposure to perinatal morphine prevented the serotonin increase. Brain expression of synapsin I mRNA was particularly abundant in cerebral cortex, hippocampus, dentate gyrus and olfactory bulb. In perinatal morphine-treated rats, the expression of synapsin I mRNA was significantly reduced; interestingly, the neonatal treatment with 6-hydroxydopamine normalized its expression. Therefore, brain-reactive neurochemical changes triggered by 6-hydroxydopamine were suppressed by perinatal morphine exposure whereas the association of morphine exposure and 6-hydroxydopamine lesion promoted the normal mRNA expression of the synaptic marker synapsin I.

AB - The effects of neonatal 6-hydroxydopamine treatment on the brain of control rats and of rats perinatally exposed to morphine were examined. Noradrenaline levels were increased in the pons-medulla, mesencephalon and caudate of 8-week-old control rats lesioned with neonatal 6-hydroxydopamine; perinatal morphine treatment prevented such an increase. In the caudate, there was a loss of dopamine and an increase of serotonin following the neurotoxic lesion; exposure to perinatal morphine prevented the serotonin increase. Brain expression of synapsin I mRNA was particularly abundant in cerebral cortex, hippocampus, dentate gyrus and olfactory bulb. In perinatal morphine-treated rats, the expression of synapsin I mRNA was significantly reduced; interestingly, the neonatal treatment with 6-hydroxydopamine normalized its expression. Therefore, brain-reactive neurochemical changes triggered by 6-hydroxydopamine were suppressed by perinatal morphine exposure whereas the association of morphine exposure and 6-hydroxydopamine lesion promoted the normal mRNA expression of the synaptic marker synapsin I.

KW - Neuronal plasticity

KW - Opiate receptor

KW - Pruning effect

KW - Synapsin I

UR - http://www.scopus.com/inward/record.url?scp=0029955353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029955353&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(96)00054-4

DO - 10.1016/0014-2999(96)00054-4

M3 - Article

C2 - 8804907

AN - SCOPUS:0029955353

VL - 303

SP - 21

EP - 26

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-2

ER -