Perinatal factors and 2-year minor neurodevelopmental impairment in low birth weight infants

A. Spinillo, E. Fazzi, S. Orcesi, P. Accorsi, F. Beccaria, E. Capuzzo

Research output: Contribution to journalArticlepeer-review


Perinatal factors were investigated in 53 low birth weight infants with minor neurodevelopmental dysfunction at 2-year follow-up and in 106 consecutive controls matched for gestational age and birth weight (within 100-gram intervals). The obstetrical history, as evaluated by the obstetrical optimality score, was significantly worse in the cases than in controls (obstetrical optimality score = 50.9 ± 5.9 vs. 53.2 ± 6.9, p = 0.019 by Mann-Whitney test). Multiple conditional logistic regression analysis showed that after adjustment for socioeconomic status and education of the mother, a low number (<3) of prenatal visits, and a third trimester hemorrhage were the only antenatal factors significantly associated with an increased risk of minor infant neurodevelopmental impairment. Neonatal acidosis (pH <7.2 in the first 24 h of life) and male gender were additional significant perinatal risk factors. Only a few antenatal and perinatal factors are correlated with subsequent minor neurodevelopmental impairment in low birth weight infants.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalBiology of the Neonate
Issue number1
Publication statusPublished - 1995


  • Low birth weight
  • Neurodevelopmental impairment
  • Obstetric factors

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health


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