Abstract
Perinatal factors were investigated in 53 low birth weight infants with minor neurodevelopmental dysfunction at 2-year follow-up and in 106 consecutive controls matched for gestational age and birth weight (within 100-gram intervals). The obstetrical history, as evaluated by the obstetrical optimality score, was significantly worse in the cases than in controls (obstetrical optimality score = 50.9 ± 5.9 vs. 53.2 ± 6.9, p = 0.019 by Mann-Whitney test). Multiple conditional logistic regression analysis showed that after adjustment for socioeconomic status and education of the mother, a low number (<3) of prenatal visits, and a third trimester hemorrhage were the only antenatal factors significantly associated with an increased risk of minor infant neurodevelopmental impairment. Neonatal acidosis (pH <7.2 in the first 24 h of life) and male gender were additional significant perinatal risk factors. Only a few antenatal and perinatal factors are correlated with subsequent minor neurodevelopmental impairment in low birth weight infants.
Original language | English |
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Pages (from-to) | 39-46 |
Number of pages | 8 |
Journal | Biology of the Neonate |
Volume | 67 |
Issue number | 1 |
Publication status | Published - 1995 |
Keywords
- Low birth weight
- Neurodevelopmental impairment
- Obstetric factors
ASJC Scopus subject areas
- Developmental Biology
- Pediatrics, Perinatology, and Child Health