Perinatal management of congenital diaphragmatic hernia

Andrea F. Conforti, Paul D. Losty

Research output: Contribution to journalArticle

Abstract

Congenital diaphragmatic hernia (CDH) retains high mortality due to lung hypoplasia and pulmonary hypertension. Efforts to improve survival and outcome have included fetal intervention, delivery at specialist centres, elective operation after stabilisation of labile physiology and minimising barotrauma. Permissive hypercapnea ('gentle ventilation') represents a significant advance in therapy gaining wider acceptance in centres worldwide. Human genetic studies are underway to identify candidate genes for the birth defect. Progress in the basic sciences may uncover critical aspects of developmental biology fundamental to CDH. Clinical trends in perinatal management of CDH are highlighted, which underpin the challenges of this lethal human anomaly.

Original languageEnglish
Pages (from-to)283-287
Number of pages5
JournalEarly Human Development
Volume82
Issue number5
DOIs
Publication statusPublished - May 2006

Fingerprint

Barotrauma
Developmental Biology
Medical Genetics
Pulmonary Hypertension
Ventilation
Lung
Survival
Mortality
Genes
Congenital Diaphragmatic Hernias
Therapeutics

Keywords

  • Congenital diaphragmatic hernia (CDH)
  • Fetus
  • Outcomes
  • Surgery

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Perinatal management of congenital diaphragmatic hernia. / Conforti, Andrea F.; Losty, Paul D.

In: Early Human Development, Vol. 82, No. 5, 05.2006, p. 283-287.

Research output: Contribution to journalArticle

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