Perinatal outcome and healthcare resource utilization in the first year of life after antiepileptic exposure during pregnancy

Daria Putignano, Antonio Clavenna, Rita Campi, Maria Paola Canevini, Aglaia Vignoli, Dina Battino, Ettore Beghi, Emilio Perucca, Angela Bortolotti, Ida Fortino, Luca Merlino, Maurizio Bonati

Research output: Contribution to journalArticle

Abstract

Healthcare administrative databases of Italy's Lombardy Region were analyzed with the aim to assess perinatal outcomes and healthcare resource utilization during the first year of life in infants exposed to antiepileptic drugs (AEDs) during pregnancy. Drug prescriptions dispensed in the 12 months before delivery to women, who delivered between 2005 and 2011, were analyzed. Neonates were classified as cases if exposed to AEDs, and each case was randomly matched to seven controls. No significant differences were observed in the risk of congenital malformations between 526 cases and 3682 controls except for valproic acid (odds ratio (OR): 2.29; 95% confidence interval (CI): 1.24-4.22) where cases were more likely to be small for gestational age (χ2 = 7.66; p = 0.006). Cases also had a higher probability than controls of needing at least one specialist visit in a child neuropsychiatry outpatient service (OR: 1.74; 95% CI: 1.22-2.49).

Original languageEnglish
Pages (from-to)14-17
Number of pages4
JournalEpilepsy and Behavior
Volume92
DOIs
Publication statusE-pub ahead of print - Dec 29 2018

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