Perindopril versus captopril: Efficacy and acceptability in an Italian multicenter trial

E. Agabiti-Rosei, E. Ambrosioni, G. Finardi, P. Folino, G. Gambassi, P. Malini, E. Marchesi, M. L. Muiesan, A. Semplicini, A. C. Pessina

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The aim of this 3-month, double-blind, double-dummy, parallel group study was to compare the antihypertensive efficacy and acceptability of perindopril (4-8 mg/day) in 54 patients (30 males, 24 females, 25-68 years of age) and captopril (50-100 mg/day) in 54 patients (39 males, 15 females, 29-66 years of age) in the treatment of essential hypertension. In a subgroup of 38 patients a complete echocardiographic study was performed. The two groups had similar (ANOVA) blood pressure (BP), heart rate (HR), body mass index, and duration of hypertension. Supine and standing BP was significantly reduced by both drugs, without differences between them. Owing to poor control of BP, hydrochlorothiazide (25 mg/day) was added to 27% of patients on perindopril and to 41% of patients on captopril (p

Original languageEnglish
JournalAmerican Journal of Medicine
Issue number4 B
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Nursing(all)


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