Perineuronal nets: Past and present

Marco R. Celio, Roberto Spreafico, Silvia De Biasi, Laura Vitellaro-Zuccarello

Research output: Contribution to journalArticle

334 Citations (Scopus)

Abstract

Golgi ranked the peripheral reticulum - which adheres intimately to nerve cell surfaces - alongside the intracellular reticulum, or Golgi apparatus, which immortalized his name. At first dismissed as an artefact of capricious staining techniques, this peripheral reticulum, or perineuronal net, is now recognized as a genuine entity in neurocytology. It represents a complex of extracellular matrix molecules interposed between the meshwork of glial processes, from which they are indistinguishable, and nerve-cell surfaces. In no other branch of neuroscience has the waxing and waning of interest in any morphological entity been so pronounced as in the case of the perineuronal net. This review traces the history of this enigmatic structure from its conception to the present time, brings to light the keen observational powers of morphologists at the turn of the century and reveals how their sagacious forethought anticipated current thinking on the role of perineuronal nets.

Original languageEnglish
Pages (from-to)510-515
Number of pages6
JournalTrends in Neurosciences
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 1 1998

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Reticulum
Neurons
Golgi Apparatus
Neurosciences
Neuroglia
Artifacts
Names
Extracellular Matrix
History
Staining and Labeling

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Celio, M. R., Spreafico, R., De Biasi, S., & Vitellaro-Zuccarello, L. (1998). Perineuronal nets: Past and present. Trends in Neurosciences, 21(12), 510-515. https://doi.org/10.1016/S0166-2236(98)01298-3

Perineuronal nets : Past and present. / Celio, Marco R.; Spreafico, Roberto; De Biasi, Silvia; Vitellaro-Zuccarello, Laura.

In: Trends in Neurosciences, Vol. 21, No. 12, 01.12.1998, p. 510-515.

Research output: Contribution to journalArticle

Celio, MR, Spreafico, R, De Biasi, S & Vitellaro-Zuccarello, L 1998, 'Perineuronal nets: Past and present', Trends in Neurosciences, vol. 21, no. 12, pp. 510-515. https://doi.org/10.1016/S0166-2236(98)01298-3
Celio MR, Spreafico R, De Biasi S, Vitellaro-Zuccarello L. Perineuronal nets: Past and present. Trends in Neurosciences. 1998 Dec 1;21(12):510-515. https://doi.org/10.1016/S0166-2236(98)01298-3
Celio, Marco R. ; Spreafico, Roberto ; De Biasi, Silvia ; Vitellaro-Zuccarello, Laura. / Perineuronal nets : Past and present. In: Trends in Neurosciences. 1998 ; Vol. 21, No. 12. pp. 510-515.
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