Abstract
Golgi ranked the peripheral reticulum - which adheres intimately to nerve cell surfaces - alongside the intracellular reticulum, or Golgi apparatus, which immortalized his name. At first dismissed as an artefact of capricious staining techniques, this peripheral reticulum, or perineuronal net, is now recognized as a genuine entity in neurocytology. It represents a complex of extracellular matrix molecules interposed between the meshwork of glial processes, from which they are indistinguishable, and nerve-cell surfaces. In no other branch of neuroscience has the waxing and waning of interest in any morphological entity been so pronounced as in the case of the perineuronal net. This review traces the history of this enigmatic structure from its conception to the present time, brings to light the keen observational powers of morphologists at the turn of the century and reveals how their sagacious forethought anticipated current thinking on the role of perineuronal nets.
| Original language | English |
|---|---|
| Pages (from-to) | 510-515 |
| Number of pages | 6 |
| Journal | Trends in Neurosciences |
| Volume | 21 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1 1998 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Perineuronal nets : Past and present. / Celio, Marco R.; Spreafico, Roberto; De Biasi, Silvia; Vitellaro-Zuccarello, Laura.
In: Trends in Neurosciences, Vol. 21, No. 12, 01.12.1998, p. 510-515.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Perineuronal nets
T2 - Past and present
AU - Celio, Marco R.
AU - Spreafico, Roberto
AU - De Biasi, Silvia
AU - Vitellaro-Zuccarello, Laura
PY - 1998/12/1
Y1 - 1998/12/1
N2 - Golgi ranked the peripheral reticulum - which adheres intimately to nerve cell surfaces - alongside the intracellular reticulum, or Golgi apparatus, which immortalized his name. At first dismissed as an artefact of capricious staining techniques, this peripheral reticulum, or perineuronal net, is now recognized as a genuine entity in neurocytology. It represents a complex of extracellular matrix molecules interposed between the meshwork of glial processes, from which they are indistinguishable, and nerve-cell surfaces. In no other branch of neuroscience has the waxing and waning of interest in any morphological entity been so pronounced as in the case of the perineuronal net. This review traces the history of this enigmatic structure from its conception to the present time, brings to light the keen observational powers of morphologists at the turn of the century and reveals how their sagacious forethought anticipated current thinking on the role of perineuronal nets.
AB - Golgi ranked the peripheral reticulum - which adheres intimately to nerve cell surfaces - alongside the intracellular reticulum, or Golgi apparatus, which immortalized his name. At first dismissed as an artefact of capricious staining techniques, this peripheral reticulum, or perineuronal net, is now recognized as a genuine entity in neurocytology. It represents a complex of extracellular matrix molecules interposed between the meshwork of glial processes, from which they are indistinguishable, and nerve-cell surfaces. In no other branch of neuroscience has the waxing and waning of interest in any morphological entity been so pronounced as in the case of the perineuronal net. This review traces the history of this enigmatic structure from its conception to the present time, brings to light the keen observational powers of morphologists at the turn of the century and reveals how their sagacious forethought anticipated current thinking on the role of perineuronal nets.
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U2 - 10.1016/S0166-2236(98)01298-3
DO - 10.1016/S0166-2236(98)01298-3
M3 - Article
C2 - 9881847
AN - SCOPUS:0032401032
VL - 21
SP - 510
EP - 515
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 12
ER -