Periodate oxidized ATP (oATP) reduces hyperalgesia in mice: Involvement of P2X7 receptors and implications for therapy

A. Fulgenzi, P. Ticozzi, C. A. Gabel, G. Dell'Antonio, A. Quattrini, J. S. Franzone, Maria Elena Ferrera

Research output: Contribution to journalArticle

Abstract

Some inflammatory mediators play an important role not only in the pathogenesis of the inflammatory pain, but also in that of neuropathic and visceral pain. We previously showed the antihyperalgesic effect of oATP, the inhibitor of the P2X7 receptors for the pro-nociceptive ATP, in experimental inflammation. Here we show the antihyperalgesic effect of oATP in mouse models of neuropathic and visceral pain, other than in a model of arthritic pain mimicking rheumatoid arthritis in humans. We also show that mice lacking P2X7 receptors (KO) are resistant to hyperalgesic thermal stimuli following the induction of arthritic, neuropathic and visceral pain. Local (injection into the right hind paw) pre-treatment with oATP is able to prevent the successive induction of ATP-dependent hyperalgesia in wild type mice. In addition, KO mice are not insensitive to intraplantar treatment with ATP. Our data suggest that, even if oATP is able to inhibit purinoceptors different from P2X7, the latter are the more important involved in pain transmission.

Original languageEnglish
Pages (from-to)61-71
Number of pages11
JournalInternational Journal of Immunopathology and Pharmacology
Volume21
Issue number1
Publication statusPublished - Jan 2008

Fingerprint

Purinergic P2X7 Receptors
Hyperalgesia
Visceral Pain
Neuralgia
Adenosine Triphosphate
Pain
Arthritis
Therapeutics
Rheumatoid Arthritis
Hot Temperature
Inflammation
Injections
periodate-oxidized adenosine 5'-triphosphate
2',3'-dialdehyde ATP

Keywords

  • Arthritic pain
  • Neuropathic pain
  • oATP
  • P2X7 receptors
  • Visceral pain

ASJC Scopus subject areas

  • Pharmacology

Cite this

Periodate oxidized ATP (oATP) reduces hyperalgesia in mice : Involvement of P2X7 receptors and implications for therapy. / Fulgenzi, A.; Ticozzi, P.; Gabel, C. A.; Dell'Antonio, G.; Quattrini, A.; Franzone, J. S.; Ferrera, Maria Elena.

In: International Journal of Immunopathology and Pharmacology, Vol. 21, No. 1, 01.2008, p. 61-71.

Research output: Contribution to journalArticle

Fulgenzi, A. ; Ticozzi, P. ; Gabel, C. A. ; Dell'Antonio, G. ; Quattrini, A. ; Franzone, J. S. ; Ferrera, Maria Elena. / Periodate oxidized ATP (oATP) reduces hyperalgesia in mice : Involvement of P2X7 receptors and implications for therapy. In: International Journal of Immunopathology and Pharmacology. 2008 ; Vol. 21, No. 1. pp. 61-71.
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