Periodic breathing during sleep in patients affected by fibromyalgia syndrome

M. Sergi, M. Rizzi, A. Braghiroli, P. Sarzi Puttini, M. Greco, M. Cazzola, A. Andreoli

Research output: Contribution to journalArticlepeer-review


Seventeen patients affected by fibromyalgia syndrome (FMS) (16 females and one male) and 17 matched healthy subjects underwent formal polysomnography, a sleep questionnaire and lung function tests. FMS patients slept significantly less efficiently than the healthy controls (p-1 kPa-1; p=0.001). PB occurrence correlated with TL,CO (r=-0.62; p=0.01), number of desaturations (r=-0.76, p=0.001) and carbon dioxide tension in arterial blood (Pa,CO2) (r=-0.50; p=0.05). Stepwise multiple linear regression analysis showed desaturation frequency (p=0.0001) and TL,CO (p=0.029) to be the best predictors of PB percentage (R2 0.73; p=0.0001). Patients complaining of daytime hypersomnolence had a higher number of tender points, about twice as many arousals per hour and a lower sleep efficiency than patients who did not report this symptom. TL,CO was more impaired and the occurrence of PB was higher. The occurrence of periodic breathing in fibromyalgia syndrome patients, which was previously unreported, and is shown to be linked to a reduction of transfer factor of the lung for carbon monoxide could play a major role in the symptoms of poor sleep of these patients.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalEuropean Respiratory Journal
Issue number1
Publication statusPublished - 1999


  • Fibromyalgia
  • Periodic breathing
  • Polysomnography
  • Sleep

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Periodic breathing during sleep in patients affected by fibromyalgia syndrome'. Together they form a unique fingerprint.

Cite this