Periodic eeg activity in the course of limbic encephalitis. a case report

Serena Buzio, Giovanni Buccino, Claudia Giorgi, Angelo Maravita, Giorgia Melli, Umberto Scoditti

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PLEDs (paroxysmal lateralized epikptifomi discharges) have been observed, after the first description in 1964, in the course of several neurological diseases. Between them there is limbic encephalitis (LE), usually associated with Herpes simplex virus (HSV 1 or 2) infection or with a sistemic malignancy. We report the case of a 67 years old man who presented partial epileptic seizures, acute confusional state, amnesia and progressive changes in behaviour. The clinical and MRI picture was consistent with the diagnosis of limbic encephalitis Cultural and serologica] examinations of blood and eerebrospinal fluid (including PCR for HSV 1 and 2) did not detect any infectious agent (Cytomegalovirus, EpsteinBair virus, Varicella-Zoster virus, HIV, HSV 1 or 2). No associated malignancy was detected, even after one year follow up.The EEG in the acute phase was characterised by a periodic activity, made up of sharp waves, on the right frontotemporal region. At a second control the periodic activity was present, in an indipendent way, also on the left frontotemporal region. The case reported is clinically similar to those recently descnbed by Fujimoto, These cases were interpreted as a new subtype of LE, with unknown etiology.We discuss the presence of periodic activity in the course of limbic encephalitis.

Original languageEnglish
Pages (from-to)98
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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