Periodic leg movements during sleep in narcoleptic patients with or without restless legs syndrome

Giuseppe Plazzi, Raffaele Ferri, Christian Franceschini, Stefano Vandi, Stefania Detto, Fabio Pizza, Francesca Poli, Valérie C. De Cock, Sophie Bayard, Yves Dauvilliers

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We compared periodic and non-periodic leg movements during sleep and polysomnography in patients with narcolepsy with cataplexy (NC) with or without restless legs syndrome (RLS) with matched idiopathic RLS (iRLS) and control subjects. We enrolled 100 patients with NC: 17 having RLS were compared with 34 sex- and age-matched patients without RLS and with 17 normal controls and 17 iRLS subjects. Periodic leg movements were highest in iRLS and lowest in controls, with those in NC with RLS very close to iRLS, but higher than those in NC without RLS. The periodicity indexes showed the highest value in iRLS followed by NC with or without RLS and, finally, by controls. The inter-leg movement intervals peaked between 10 and 50s in NC with RLS and in iRLS, the former did not display the nocturnal gradual decrease of periodic leg movements typical of iRLS. Periodic leg movements during sleep and polysomnography displayed specific features in RLS and NC, respectively, with NC with RLS showing an intermediate pattern. Even if RLS is only detected by targeted interview in NC, its frequency and impact on night-time sleep architecture and continuity suggest that this condition should be routinely searched for in NC.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalJournal of Sleep Research
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 2012

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Cataplexy
Restless Legs Syndrome
Narcolepsy
Leg
Sleep
Polysomnography
Periodicity

Keywords

  • Narcolepsy with cataplexy
  • Periodic limb movements during sleep
  • Restless legs syndrome

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Medicine(all)

Cite this

Periodic leg movements during sleep in narcoleptic patients with or without restless legs syndrome. / Plazzi, Giuseppe; Ferri, Raffaele; Franceschini, Christian; Vandi, Stefano; Detto, Stefania; Pizza, Fabio; Poli, Francesca; De Cock, Valérie C.; Bayard, Sophie; Dauvilliers, Yves.

In: Journal of Sleep Research, Vol. 21, No. 2, 04.2012, p. 155-162.

Research output: Contribution to journalArticle

Plazzi, Giuseppe ; Ferri, Raffaele ; Franceschini, Christian ; Vandi, Stefano ; Detto, Stefania ; Pizza, Fabio ; Poli, Francesca ; De Cock, Valérie C. ; Bayard, Sophie ; Dauvilliers, Yves. / Periodic leg movements during sleep in narcoleptic patients with or without restless legs syndrome. In: Journal of Sleep Research. 2012 ; Vol. 21, No. 2. pp. 155-162.
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