Movimenti periodici agli arti inferiori durante sonno (PLMs) ed epilessia: Associazione o comorbidità?

Translated title of the contribution: Periodic Leg Movements During Sleep (PLMs) and Epilepsy: Association or comorbidity?

I. Pappalardo, V. Sofia, G. Vitale, P. Magnano San Lio, V. Lingenti, L. Giuliano, C. Sueri, M. Zappia

Research output: Contribution to journalArticle

Abstract

Objective: only a few studies have documented the presence of pathological periodic leg movements during sleep (PLMs) in patients with epilepsy. The aim of this retrospective analysis was to evaluate the existence of association between PLMs and epilepsy. Materials and methods: patients monitored with Video-Polysomnography in our hospital in the last year with diagnosis of epilepsy, were screened retrospectively for the presence of PLM index > 5. Criteria of exclusion were: age over 60 and the presence of Obstructive Sleep Apnea (OSA), Restless Legs Syndrome (RLS), REM Sleep Behaviour Disorder (RBD), Neurodegenerative Disease or therapy with antidepressant and/or antidopaminergic drugs. Results: we considered 85 patients with epilepsy. Nine patients (20%) had pathological PLMs (12 women, 5 men; age of 42,4±9,8 years). Twelve of them (70%) had a temporal lobe epilepsy, two (11%) had frontal lobe epilepsy and three (17%) had juvenile myoclonic epilepsy. Myoclonic movements occurred mainly in the first half of the night, coinciding with N2, with mild to moderate severity. They had a distribution that made them more similar to PLMs in RLS, than those associated with neurodegenerative diseases. Discussion and conclusions: our study confirms the presence of PLMs in patients with epilepsy. It could be explained by the fragmented structure of sleep often found in epileptic patients and secondary to epileptic discharges. Given the dopaminergic nature of PLMs, their presence in epilepsy could strengthen the role of dopamine in the pathophysiology of epilepsy.

Translated title of the contributionPeriodic Leg Movements During Sleep (PLMs) and Epilepsy: Association or comorbidity?
Original languageItalian
Pages (from-to)38-42
Number of pages5
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number144
Publication statusPublished - May 2012

ASJC Scopus subject areas

  • Clinical Neurology

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    Pappalardo, I., Sofia, V., Vitale, G., Magnano San Lio, P., Lingenti, V., Giuliano, L., Sueri, C., & Zappia, M. (2012). Movimenti periodici agli arti inferiori durante sonno (PLMs) ed epilessia: Associazione o comorbidità? Bollettino - Lega Italiana contro l'Epilessia, (144), 38-42.