Periodontal disease as a risk factor for adverse pregnancy outcomes: A systematic review and meta-analysis of case-control studies

Stefano Corbella, Silvio Taschieri, Luca Francetti, Francesca de Siena, Massimo Del Fabbro

Research output: Contribution to journalArticlepeer-review

Abstract

Periodontal disease is a highly prevalent group of illnesses of microbial etiology, whose consequence is a severe breakdown of tooth-supporting structures. A link between periodontal infection and several systemic conditions, among which adverse pregnancy outcomes, has been suggested in the recent years. The aim of this review based on case-control studies was to evaluate if periodontal disease could be considered as a risk factor for preterm birth, low birth-weight and preterm low birth-weight. An electronic search (via Pubmed) was performed for case-control studies investigating the relationship between periodontal disease and adverse pregnancy outcomes. From the initially retrieved 417 articles, 17 case-control studies, accounting for a total of 10,148 patients, were included in the review and in the meta-analysis. The estimated odds ratio was 1.78 (CI 95%: 1.58, 2.01) for preterm birth, 1.82 (CI 95%: 1.51, 1.20) for low birth-weight and 3.00 (CI 95%: 1.93, 4.68) for preterm low birth-weight. Despite the results of the analysis of pooled data suggested a link between periodontal diseases and adverse pregnancy outcomes, the presence of important confounders, whose effect could not be addressed, prevents a validation of the meta-analysis outcomes. Further more accurate investigations based on individual data analysis could give a better insight into the topic of the present review.

Original languageEnglish
Pages (from-to)232-240
Number of pages9
JournalOdontology
Volume100
Issue number2
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Adverse pregnancy outcomes
  • Meta-analysis
  • Periodontal diseases
  • Periodontitis
  • Risk factor

ASJC Scopus subject areas

  • Dentistry(all)

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