Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities

F. Bertoni, S. Boriani, M. Laus, M. Campanacci

Research output: Contribution to journalArticlepeer-review


This review of 27 cases serves to emphasise that periosteal chondrosarcoma and periosteal osteosarcoma are two distinct entities. Clinically, periosteal chondrosarcoma is less painful than periosteal osteosarcoma and runs a slower course. Radiographically, periosteal chondrosarcoma tends to affect the metaphysis and contains granular or 'popcorn' opacities; while periosteal osteosarcoma more often affects the mid-diaphysis and shows lytic lesions with some spicules of reactive bone perpendicular to the underlying cortex. Histologically, periosteal chondrosarcoma shows lobular well-differentiated cartilage with Grade I or II (rarely Grade III) malignancy; periosteal osteosarcoma has a chondroid matrix with some osteoid component and Grade II or III malignancy. The prognosis in periosteal chondrosarcoma is good; conservative surgery is usually effective and metastases are very uncommon. In periosteal osteosarcoma the prognosis is less satisfactory but is better than that of other osteosarcomata; wide surgical excision is, however, needed and the incidence of metastases is about 15%.

Original languageEnglish
Pages (from-to)370-376
Number of pages7
JournalJournal of Bone and Joint Surgery - Series B
Issue number3
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery


Dive into the research topics of 'Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities'. Together they form a unique fingerprint.

Cite this