Abstract
Background: Allergic asthma is characterized by type 2 inflammation. Periostin has been proposed as type 2 biomarker. Objective: To test the hypothesis that serum periostin could be associated with the asthma control grade in a group of children with allergic asthma and recruited in clinical practice. Patients and methods: 121 consecutive children (71 males, 50 females, mean age 11.6 ± 3.2 years) with allergic asthma were visited for the first time at a third-level paediatric clinic. Serum periostin was evaluated with gender, BMI and z score BMI, lung function, FeNO, ACT questionnaire, VAS of breathing perception, peripheral eosinophils, total serum IgE, oral corticosteroid (CS) use in the past year, control asthma grade and asthma severity (according to GINA document). Results: Serum periostin was not associated with the asthma control grade and did not correlate with blood eosinophils and FeNO. In addition, peripheral eosinophils, serum IgE, and FeNO were not associated with the asthma control grade. On the contrary, gender, FEV 1 , FEV 1 /FVC ratio, FEF 25-75 , ACT, VAS of breathing perception, oral corticosteroid use, and asthma severity grade were associated with the asthma control grade. Conclusions: Serum periostin seems to be scarcely useful to assess the asthma control in children with allergic asthma in clinical practice. There is the need to identify reliable inflammation biomarkers able to correlate with the asthma control grade.
| Original language | English |
|---|---|
| Pages (from-to) | 118-120 |
| Number of pages | 3 |
| Journal | Respiratory Medicine |
| Volume | 151 |
| DOIs | |
| Publication status | Published - May 1 2019 |
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Keywords
- Asthma
- Asthma control
- Children
- Eosinophils
- Inflammation
- Periostin
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Periostin, type 2 biomarker, is not associated with asthma control grade in asthmatic allergic children. / Licari, Amelia; Brambilla, Ilaria; Sacchi, Lucia; Marseglia, Gianluigi; Ciprandi, Giorgio.
In: Respiratory Medicine, Vol. 151, 01.05.2019, p. 118-120.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Periostin, type 2 biomarker, is not associated with asthma control grade in asthmatic allergic children
AU - Licari, Amelia
AU - Brambilla, Ilaria
AU - Sacchi, Lucia
AU - Marseglia, Gianluigi
AU - Ciprandi, Giorgio
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Background: Allergic asthma is characterized by type 2 inflammation. Periostin has been proposed as type 2 biomarker. Objective: To test the hypothesis that serum periostin could be associated with the asthma control grade in a group of children with allergic asthma and recruited in clinical practice. Patients and methods: 121 consecutive children (71 males, 50 females, mean age 11.6 ± 3.2 years) with allergic asthma were visited for the first time at a third-level paediatric clinic. Serum periostin was evaluated with gender, BMI and z score BMI, lung function, FeNO, ACT questionnaire, VAS of breathing perception, peripheral eosinophils, total serum IgE, oral corticosteroid (CS) use in the past year, control asthma grade and asthma severity (according to GINA document). Results: Serum periostin was not associated with the asthma control grade and did not correlate with blood eosinophils and FeNO. In addition, peripheral eosinophils, serum IgE, and FeNO were not associated with the asthma control grade. On the contrary, gender, FEV 1 , FEV 1 /FVC ratio, FEF 25-75 , ACT, VAS of breathing perception, oral corticosteroid use, and asthma severity grade were associated with the asthma control grade. Conclusions: Serum periostin seems to be scarcely useful to assess the asthma control in children with allergic asthma in clinical practice. There is the need to identify reliable inflammation biomarkers able to correlate with the asthma control grade.
AB - Background: Allergic asthma is characterized by type 2 inflammation. Periostin has been proposed as type 2 biomarker. Objective: To test the hypothesis that serum periostin could be associated with the asthma control grade in a group of children with allergic asthma and recruited in clinical practice. Patients and methods: 121 consecutive children (71 males, 50 females, mean age 11.6 ± 3.2 years) with allergic asthma were visited for the first time at a third-level paediatric clinic. Serum periostin was evaluated with gender, BMI and z score BMI, lung function, FeNO, ACT questionnaire, VAS of breathing perception, peripheral eosinophils, total serum IgE, oral corticosteroid (CS) use in the past year, control asthma grade and asthma severity (according to GINA document). Results: Serum periostin was not associated with the asthma control grade and did not correlate with blood eosinophils and FeNO. In addition, peripheral eosinophils, serum IgE, and FeNO were not associated with the asthma control grade. On the contrary, gender, FEV 1 , FEV 1 /FVC ratio, FEF 25-75 , ACT, VAS of breathing perception, oral corticosteroid use, and asthma severity grade were associated with the asthma control grade. Conclusions: Serum periostin seems to be scarcely useful to assess the asthma control in children with allergic asthma in clinical practice. There is the need to identify reliable inflammation biomarkers able to correlate with the asthma control grade.
KW - Asthma
KW - Asthma control
KW - Children
KW - Eosinophils
KW - Inflammation
KW - Periostin
UR - http://www.scopus.com/inward/record.url?scp=85064162940&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064162940&partnerID=8YFLogxK
U2 - 10.1016/j.rmed.2019.04.010
DO - 10.1016/j.rmed.2019.04.010
M3 - Article
AN - SCOPUS:85064162940
VL - 151
SP - 118
EP - 120
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
ER -