Peripapillary vessel density changes in Leber's hereditary optic neuropathy: a new biomarker

N Balducci, Maria Lucia Cascavilla, A Ciardella, C La Morgia, Giacinto Triolo, V Parisi, F Bandello, AA Sadun, V Carelli, Piero Barboni

Research output: Contribution to journalArticlepeer-review


Importance: The contribution of the microvascular supply to the pathogenesis of Leber's hereditary optic neuropathy (LHON) is poorly understood. Background: We aimed at measuring the peripapillary capillary vessel density (VD) using optical coherence tomography angiography (OCT-A) at different stages of LHON. Design: Prospective, cross-sectional, multicenter, observational study. Participants: Twenty-two LHON patients divided in four groups: unaffected mutation carriers (LHON-u); early sub-acute stage (LHON-e); late sub-acute stage (LHON-l); chronic stage (LHON-ch). Methods: OCT-A scans centred on the optic disc were obtained by spectral domain OCT system. Main Outcome Measures: VD, retinal nerve fibre layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness were compared between groups. Results: Significant VD changes were detected in every sector (P <0.0001). In LHON-e, the VD was reduced in the temporal sector compared with LHON-u and in the temporal and inferotemporal sectors compared with controls. In LHON-l, VD was reduced in whole, temporal, superotemporal and inferotemporal sectors compared with LHON-u and controls. In LHON-ch, the VD was reduced in all sectors compared to the other groups. An asynchronous pattern emerged in the temporal sector with VD changes occurring earlier than RNFL thickness changes and together with GC-IPL thinning. Conclusions and Relevance: Significant peripapillary miscrovascular changes were detected over the different stages of LHON. Studying the vascular network separately from fibres revealed that microvascular changes in the temporal sector preceded the changes of RNFL and mirrored the GC-IPL changes. Measurements of the peripapillary vascular network may become a useful biomarker to monitor the disease process, evaluate therapeutic efficacy and elucidate pathophysiology. © 2018 Royal Australian and New Zealand College of Ophthalmologists
Original languageEnglish
Pages (from-to)1055-1062
Number of pages8
JournalClinical and Experimental Ophthalmology
Issue number9
Publication statusPublished - 2018


Dive into the research topics of 'Peripapillary vessel density changes in Leber's hereditary optic neuropathy: a new biomarker'. Together they form a unique fingerprint.

Cite this