TY - JOUR
T1 - Peripersonal Visuospatial Abilities in Williams Syndrome Analyzed by a Table Radial Arm Maze Task
AU - Foti, Francesca
AU - Sorrentino, Pierpaolo
AU - Menghini, Deny
AU - Montuori, Simone
AU - Pesoli, Matteo
AU - Turriziani, Patrizia
AU - Vicari, Stefano
AU - Petrosini, Laura
AU - Mandolesi, Laura
N1 - Funding Information:
We would like to thank F. Gelfo for her valuable suggestions. Funding. This research was supported by funding from the Foundation J?r?me Lejeune to LM (n. 1567, 2016B) and from the Association ?Autour des Williams? to FF.
Publisher Copyright:
© Copyright © 2020 Foti, Sorrentino, Menghini, Montuori, Pesoli, Turriziani, Vicari, Petrosini and Mandolesi.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/7/20
Y1 - 2020/7/20
N2 - Williams syndrome (WS) is a genetic deletion syndrome characterized by severe visuospatial deficits affecting spatial exploration and navigation abilities in extra-personal space.To date, little is known about spatial elaboration and reaching abilities in the peripersonal space in individuals with WS. The present study is aimed at evaluating the visuospatial abilities in individuals with WS and comparing their performances with those of mental age-matched typically developing (TD) children by using a highly sensitive ecological version of the Radial Arm Maze (table RAM). We evaluated 15 individuals with WS and 15 TD children in two different table RAM paradigms: the free-choice paradigm, mainly to analyze the aspects linked to procedural and memory components, and the forced-choice paradigm, to disentangle the components linked to spatial working memory from the procedural ones.Data show that individuals with WS made significantly more working memory errors as compared with TD children, thus evidencing a marked deficit in resolving the task when the mnesic load increased. Our findings provide new insights on the cognitive profile of WS.
AB - Williams syndrome (WS) is a genetic deletion syndrome characterized by severe visuospatial deficits affecting spatial exploration and navigation abilities in extra-personal space.To date, little is known about spatial elaboration and reaching abilities in the peripersonal space in individuals with WS. The present study is aimed at evaluating the visuospatial abilities in individuals with WS and comparing their performances with those of mental age-matched typically developing (TD) children by using a highly sensitive ecological version of the Radial Arm Maze (table RAM). We evaluated 15 individuals with WS and 15 TD children in two different table RAM paradigms: the free-choice paradigm, mainly to analyze the aspects linked to procedural and memory components, and the forced-choice paradigm, to disentangle the components linked to spatial working memory from the procedural ones.Data show that individuals with WS made significantly more working memory errors as compared with TD children, thus evidencing a marked deficit in resolving the task when the mnesic load increased. Our findings provide new insights on the cognitive profile of WS.
KW - children
KW - ecological behavioral task
KW - navigation abilities
KW - spatial exploration
KW - spatial memory
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U2 - 10.3389/fnhum.2020.00254
DO - 10.3389/fnhum.2020.00254
M3 - Article
AN - SCOPUS:85088967106
VL - 14
JO - Frontiers in Human Neuroscience
JF - Frontiers in Human Neuroscience
SN - 1662-5161
M1 - 254
ER -