Peripersonal Visuospatial Abilities in Williams Syndrome Analyzed by a Table Radial Arm Maze Task

Francesca Foti, Pierpaolo Sorrentino, Deny Menghini, Simone Montuori, Matteo Pesoli, Patrizia Turriziani, Stefano Vicari, Laura Petrosini, Laura Mandolesi

Research output: Contribution to journalArticlepeer-review

Abstract

Williams syndrome (WS) is a genetic deletion syndrome characterized by severe visuospatial deficits affecting spatial exploration and navigation abilities in extra-personal space.To date, little is known about spatial elaboration and reaching abilities in the peripersonal space in individuals with WS. The present study is aimed at evaluating the visuospatial abilities in individuals with WS and comparing their performances with those of mental age-matched typically developing (TD) children by using a highly sensitive ecological version of the Radial Arm Maze (table RAM). We evaluated 15 individuals with WS and 15 TD children in two different table RAM paradigms: the free-choice paradigm, mainly to analyze the aspects linked to procedural and memory components, and the forced-choice paradigm, to disentangle the components linked to spatial working memory from the procedural ones.Data show that individuals with WS made significantly more working memory errors as compared with TD children, thus evidencing a marked deficit in resolving the task when the mnesic load increased. Our findings provide new insights on the cognitive profile of WS.

Original languageEnglish
Article number254
JournalFrontiers in Human Neuroscience
Volume14
DOIs
Publication statusPublished - Jul 20 2020

Keywords

  • children
  • ecological behavioral task
  • navigation abilities
  • spatial exploration
  • spatial memory

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

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