Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients

Irene Ciancarelli, Daniela De Amicis, Caterina Di Massimo, Carla Di Scanno, Caterina Pistarini, Nicolantonio D'Orazio, Maria Giuliana Tozzi Ciancarelli

Research output: Contribution to journalArticle

Abstract

Context: Peripheral oxidative biomarkers could be useful for monitoring clinical features of Huntington's disease (HD). Materials and methods: Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-2′-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients. Results: Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed. Discussion and conclusion: Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.

Original languageEnglish
Pages (from-to)452-456
Number of pages5
JournalBiomarkers
Volume19
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Biomarkers
  • Huntington's disease
  • Neuronal oxidative damage
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

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    Ciancarelli, I., De Amicis, D., Di Massimo, C., Di Scanno, C., Pistarini, C., D'Orazio, N., & Tozzi Ciancarelli, M. G. (2014). Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients. Biomarkers, 19(6), 452-456. https://doi.org/10.3109/1354750X.2014.935955