Peripheral blood abnormalities in Alzheimer disease: Evidence for early endothelial dysfunction

B. Borroni, R. Volpi, G. Martini, R. Del Bono, S. Archetti, F. Colciaghi, N. Maalikjy Akkawi, M. Di Luca, G. Romanelli, L. Caimi, A. Padovani

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical and epidemiologic studies demonstrate that vascular risk factors may be involved in Alzheimer disease (AD). To evaluate whether vascular abnormalities are an early feature of AD, several parameters of coagulation and fibrinolysis were assessed. Thirty patients with mild AD and 30 age-matched control subjects entered the study. All subjects performed a standardized clinical and laboratory protocol. Persons with vascular risk factors and systemic diseases were excluded. AD patients present significant increased levels of thrombomodulin (p <0.0001) and sE-selectin (p <0.03). In contrast, no difference was found between the two diagnostic groups in the levels of β-thromboglobulin, prothrombin fragment 1+2, fibrinogen, and von Willebrand factor. No other association but diagnosis was found with thrombomodulin and sE-selectin. These findings suggest that endothelial dysfunction is an early event in AD patients.

Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalAlzheimer Disease and Associated Disorders
Volume16
Issue number3
DOIs
Publication statusPublished - Jul 2002

Keywords

  • Alzheimer disease
  • Endothelial dysfunction
  • Hemostasis changes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)

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