Peripheral blood abnormalities in Alzheimer disease: Evidence for early endothelial dysfunction

B. Borroni, R. Volpi, G. Martini, R. Del Bono, S. Archetti, F. Colciaghi, N. Maalikjy Akkawi, M. Di Luca, G. Romanelli, L. Caimi, A. Padovani

Research output: Contribution to journalArticle

Abstract

Clinical and epidemiologic studies demonstrate that vascular risk factors may be involved in Alzheimer disease (AD). To evaluate whether vascular abnormalities are an early feature of AD, several parameters of coagulation and fibrinolysis were assessed. Thirty patients with mild AD and 30 age-matched control subjects entered the study. All subjects performed a standardized clinical and laboratory protocol. Persons with vascular risk factors and systemic diseases were excluded. AD patients present significant increased levels of thrombomodulin (p <0.0001) and sE-selectin (p <0.03). In contrast, no difference was found between the two diagnostic groups in the levels of β-thromboglobulin, prothrombin fragment 1+2, fibrinogen, and von Willebrand factor. No other association but diagnosis was found with thrombomodulin and sE-selectin. These findings suggest that endothelial dysfunction is an early event in AD patients.

Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalAlzheimer Disease and Associated Disorders
Volume16
Issue number3
DOIs
Publication statusPublished - Jul 2002

Fingerprint

Alzheimer Disease
Thrombomodulin
Selectins
von Willebrand Factor
Fibrinolysis
Clinical Protocols
Fibrinogen
Blood Vessels
Epidemiologic Studies
vascular factor

Keywords

  • Alzheimer disease
  • Endothelial dysfunction
  • Hemostasis changes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Borroni, B., Volpi, R., Martini, G., Del Bono, R., Archetti, S., Colciaghi, F., ... Padovani, A. (2002). Peripheral blood abnormalities in Alzheimer disease: Evidence for early endothelial dysfunction. Alzheimer Disease and Associated Disorders, 16(3), 150-155. https://doi.org/10.1097/00002093-200207000-00004

Peripheral blood abnormalities in Alzheimer disease : Evidence for early endothelial dysfunction. / Borroni, B.; Volpi, R.; Martini, G.; Del Bono, R.; Archetti, S.; Colciaghi, F.; Maalikjy Akkawi, N.; Di Luca, M.; Romanelli, G.; Caimi, L.; Padovani, A.

In: Alzheimer Disease and Associated Disorders, Vol. 16, No. 3, 07.2002, p. 150-155.

Research output: Contribution to journalArticle

Borroni, B, Volpi, R, Martini, G, Del Bono, R, Archetti, S, Colciaghi, F, Maalikjy Akkawi, N, Di Luca, M, Romanelli, G, Caimi, L & Padovani, A 2002, 'Peripheral blood abnormalities in Alzheimer disease: Evidence for early endothelial dysfunction', Alzheimer Disease and Associated Disorders, vol. 16, no. 3, pp. 150-155. https://doi.org/10.1097/00002093-200207000-00004
Borroni, B. ; Volpi, R. ; Martini, G. ; Del Bono, R. ; Archetti, S. ; Colciaghi, F. ; Maalikjy Akkawi, N. ; Di Luca, M. ; Romanelli, G. ; Caimi, L. ; Padovani, A. / Peripheral blood abnormalities in Alzheimer disease : Evidence for early endothelial dysfunction. In: Alzheimer Disease and Associated Disorders. 2002 ; Vol. 16, No. 3. pp. 150-155.
@article{6a623f8a14fd41cc9b627259e2307e31,
title = "Peripheral blood abnormalities in Alzheimer disease: Evidence for early endothelial dysfunction",
abstract = "Clinical and epidemiologic studies demonstrate that vascular risk factors may be involved in Alzheimer disease (AD). To evaluate whether vascular abnormalities are an early feature of AD, several parameters of coagulation and fibrinolysis were assessed. Thirty patients with mild AD and 30 age-matched control subjects entered the study. All subjects performed a standardized clinical and laboratory protocol. Persons with vascular risk factors and systemic diseases were excluded. AD patients present significant increased levels of thrombomodulin (p <0.0001) and sE-selectin (p <0.03). In contrast, no difference was found between the two diagnostic groups in the levels of β-thromboglobulin, prothrombin fragment 1+2, fibrinogen, and von Willebrand factor. No other association but diagnosis was found with thrombomodulin and sE-selectin. These findings suggest that endothelial dysfunction is an early event in AD patients.",
keywords = "Alzheimer disease, Endothelial dysfunction, Hemostasis changes",
author = "B. Borroni and R. Volpi and G. Martini and {Del Bono}, R. and S. Archetti and F. Colciaghi and {Maalikjy Akkawi}, N. and {Di Luca}, M. and G. Romanelli and L. Caimi and A. Padovani",
year = "2002",
month = "7",
doi = "10.1097/00002093-200207000-00004",
language = "English",
volume = "16",
pages = "150--155",
journal = "Alzheimer Disease and Associated Disorders",
issn = "0893-0341",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Peripheral blood abnormalities in Alzheimer disease

T2 - Evidence for early endothelial dysfunction

AU - Borroni, B.

AU - Volpi, R.

AU - Martini, G.

AU - Del Bono, R.

AU - Archetti, S.

AU - Colciaghi, F.

AU - Maalikjy Akkawi, N.

AU - Di Luca, M.

AU - Romanelli, G.

AU - Caimi, L.

AU - Padovani, A.

PY - 2002/7

Y1 - 2002/7

N2 - Clinical and epidemiologic studies demonstrate that vascular risk factors may be involved in Alzheimer disease (AD). To evaluate whether vascular abnormalities are an early feature of AD, several parameters of coagulation and fibrinolysis were assessed. Thirty patients with mild AD and 30 age-matched control subjects entered the study. All subjects performed a standardized clinical and laboratory protocol. Persons with vascular risk factors and systemic diseases were excluded. AD patients present significant increased levels of thrombomodulin (p <0.0001) and sE-selectin (p <0.03). In contrast, no difference was found between the two diagnostic groups in the levels of β-thromboglobulin, prothrombin fragment 1+2, fibrinogen, and von Willebrand factor. No other association but diagnosis was found with thrombomodulin and sE-selectin. These findings suggest that endothelial dysfunction is an early event in AD patients.

AB - Clinical and epidemiologic studies demonstrate that vascular risk factors may be involved in Alzheimer disease (AD). To evaluate whether vascular abnormalities are an early feature of AD, several parameters of coagulation and fibrinolysis were assessed. Thirty patients with mild AD and 30 age-matched control subjects entered the study. All subjects performed a standardized clinical and laboratory protocol. Persons with vascular risk factors and systemic diseases were excluded. AD patients present significant increased levels of thrombomodulin (p <0.0001) and sE-selectin (p <0.03). In contrast, no difference was found between the two diagnostic groups in the levels of β-thromboglobulin, prothrombin fragment 1+2, fibrinogen, and von Willebrand factor. No other association but diagnosis was found with thrombomodulin and sE-selectin. These findings suggest that endothelial dysfunction is an early event in AD patients.

KW - Alzheimer disease

KW - Endothelial dysfunction

KW - Hemostasis changes

UR - http://www.scopus.com/inward/record.url?scp=18544375622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18544375622&partnerID=8YFLogxK

U2 - 10.1097/00002093-200207000-00004

DO - 10.1097/00002093-200207000-00004

M3 - Article

C2 - 12218645

AN - SCOPUS:18544375622

VL - 16

SP - 150

EP - 155

JO - Alzheimer Disease and Associated Disorders

JF - Alzheimer Disease and Associated Disorders

SN - 0893-0341

IS - 3

ER -