Peripheral blood CD3 and CD4 T-lymphocyte reduction correlates with severity of liver cirrhosis

L. Lombardo, A. Capaldi, G. Poccardi, P. Vineis

Research output: Contribution to journalArticle

Abstract

Immunological disturbances with impairment of immune function and a higher incidence of lymphoproliferative disorders and other malignancies have been described in liver cirrhosis patients. To investigate the pathogenetic mechanism(s) involved in such associated we looked for a possible imbalance in peripheral blood T-lymphocyte subpopulations in patients with liver cirrhosis of differing severity. Immunophenotyping and counts of peripheral blood T-lymphocyte subpopulations were carried out using monoclonal antibodies conjugated with different fluorochromes in 31 consecutive cirrhotic patients and 23 matched healthy volunteers. Univariate and multivariate analyses of lymphocyte phenotype counts were performed and odds ratios were computed. Statistically significant associations, according to both univariate and multivariate analyses, were found between case/control status and mean CD3 and CD4 T-lymphocyte counts (P

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalInternational Journal of Clinical & Laboratory Research
Volume25
Issue number3
DOIs
Publication statusPublished - Sep 1995

Keywords

  • Liver cirrhosis
  • Peripheral blood CD3
  • Peripheral blood CD4 T-lymphocytes
  • Pugh's classification
  • T lymphocytes

ASJC Scopus subject areas

  • Clinical Biochemistry

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