Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers

Francesco Autore, Nicola Piccirillo, Andrea Nozza, Idanna Innocenti, Rossana Putzulu, Patrizia Chiusolo, Federica Sora, Gina Zini, Andrea Bacigalupo, Luca Castagna, Simona Sica, Stefania Bramanti, Luca Laurenti

Research output: Contribution to journalArticle

Abstract

Autologous peripheral blood stem cell transplantation should be considered first-line therapy in young patients with POEMS. The best protocol to collect peripheral blood stem cells remains to be defined, because of the disease rarity and the heterogeneity of published case series. We collected clinical and laboratory data from 25 patients undergoing mobilization, of whom 11 were mobilized using cyclophosphamide (CY) followed by granulocyte colony-stimulating factor (G-CSF) and 14 patients using G-CSF. The incidence of poor mobilization was low and not statistically different between the 2 groups. Both schemes (CY plus G-CSF versus G-CSF alone) were able to harvest a sufficient CD34+ cell dose.
Original languageEnglish
Pages (from-to)2514-2516
Number of pages3
JournalBiology of Blood and Marrow Transplantation
Volume25
Issue number12
DOIs
Publication statusPublished - Dec 2019

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