Peripheral blood lymphocyte subpopulations after splenectomy for trauma.

G. Chelazzi, G. Senaldi, G. Pinotti, C. Nicora, D. Rossi, M. Mondelli

Research output: Contribution to journalArticlepeer-review


Absolute and percent numbers of peripheral blood lymphocyte (PBL) subpopulations were evaluated using monoclonal antibodies in 20 subjects splenectomised for trauma. A significant increase was observed in the absolute counts of total PBL, B, null and Leu 7+ cells and in the percent counts of null and Leu 7+ lymphocytes. The percent numbers of OKT11+, OKT4+ and OKT8+ lymphocytes were significantly reduced, but the OKT4+/OKT8+ ratio was not statistically different from normal controls. The increase in B and killer/natural killer cells may provide a compensatory mechanism responsible for surveillance against infections and tumors in splenectomised patients, despite the numerous humoral and cellular abnormalities they commonly display.

Original languageEnglish
Pages (from-to)120-123
Number of pages4
JournalBollettino dell'Istituto Sieroterapico Milanese
Issue number2
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Immunology


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