Peripheral blood lymphocyte subpopulations after splenectomy for trauma.

G. Chelazzi, G. Senaldi, G. Pinotti, C. Nicora, D. Rossi, M. Mondelli

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Absolute and percent numbers of peripheral blood lymphocyte (PBL) subpopulations were evaluated using monoclonal antibodies in 20 subjects splenectomised for trauma. A significant increase was observed in the absolute counts of total PBL, B, null and Leu 7+ cells and in the percent counts of null and Leu 7+ lymphocytes. The percent numbers of OKT11+, OKT4+ and OKT8+ lymphocytes were significantly reduced, but the OKT4+/OKT8+ ratio was not statistically different from normal controls. The increase in B and killer/natural killer cells may provide a compensatory mechanism responsible for surveillance against infections and tumors in splenectomised patients, despite the numerous humoral and cellular abnormalities they commonly display.

Original languageEnglish
Pages (from-to)120-123
Number of pages4
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume66
Issue number2
Publication statusPublished - 1987

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Lymphocyte Subsets
Splenectomy
Lymphocytes
Null Lymphocytes
Wounds and Injuries
Natural Killer Cells
Monoclonal Antibodies
Infection
Neoplasms

ASJC Scopus subject areas

  • Immunology

Cite this

Peripheral blood lymphocyte subpopulations after splenectomy for trauma. / Chelazzi, G.; Senaldi, G.; Pinotti, G.; Nicora, C.; Rossi, D.; Mondelli, M.

In: Bollettino dell'Istituto Sieroterapico Milanese, Vol. 66, No. 2, 1987, p. 120-123.

Research output: Contribution to journalArticle

Chelazzi, G, Senaldi, G, Pinotti, G, Nicora, C, Rossi, D & Mondelli, M 1987, 'Peripheral blood lymphocyte subpopulations after splenectomy for trauma.', Bollettino dell'Istituto Sieroterapico Milanese, vol. 66, no. 2, pp. 120-123.
Chelazzi, G. ; Senaldi, G. ; Pinotti, G. ; Nicora, C. ; Rossi, D. ; Mondelli, M. / Peripheral blood lymphocyte subpopulations after splenectomy for trauma. In: Bollettino dell'Istituto Sieroterapico Milanese. 1987 ; Vol. 66, No. 2. pp. 120-123.
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