Peripheral blood mobilization of hematopoietic stem cells: Cytokine-mediated regulation of adhesive interactions within the hematopoietic microenvironment

Maria Alessandra Santucci, Roberto Massimo Lemoli, Sante Tura

Research output: Contribution to journalArticle

Abstract

Peripheral blood (PB) mobilization of hematopoietic progenitors, presently regarded as an alternative source of cells intended for autologous or allogeneic bone marrow (BM) transplantation, supports a role for cytokines in the regulated adhesion of hematopoietic compartments to the BM microenvironment. Two major consequences might result from cytokine-induced rearrangements of adhesive interactions within the hematopoietic tissue, both potentially relevant for clinical purposes of PB grafts. The first one, arising from abrogated adhesion of hematopoietic stem cells to their microenvironmental 'niche', which is critical for the maintenance of cell cycle quiescence and endurability, might result in some impairment of the long-term repopulating potential of PB grafts. The second and possibly more harmful one is due to the inability of the cytokine to distinguish between normal and transformed cells, and would likely result in graft contamination by tumor cells, increasing the metastasizing potential of hematological malignancies and solid tumors.

Original languageEnglish
Pages (from-to)90-96
Number of pages7
JournalActa Haematologica
Volume97
Issue number1-2
Publication statusPublished - Dec 1996

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Keywords

  • Adhesion
  • Cytokines
  • Hematopoietic stem cell mobilization
  • Peripheral blood autografts

ASJC Scopus subject areas

  • Hematology

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