Peripheral blood mononuclear cell β-endorphin concentration is decreased in chronic fatigue syndrome and fibromyalgia but not in depression: Preliminary report

Alberto E. Panerai, Jacopo Vecchiet, Paolo Panzeri, PierLuigi Meroni, Silvio Scarone, Eligio Pizzigallo, Maria Adele Giamberardino, Paola Sacerdote

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The aim of this study was to examine the possible role of the immune system in the pathophysiology of chronic fatigue syndrome and fibromyalgia syndrome and in the differential diagnosis of depression by investigating changes in peripheral blood mononuclear cell levels of β-endorphin, an endogenous opioid known to be involved in regulation of the immune system function. Design: β-Endorphin concentrations were measured by radioimmunoassay in peripheral blood mononuclear cells from healthy controls (n = 8) and patients with chronic fatigue syndrome (n = 17), fibromyalgia syndrome (n = 5), or depression (n = 10). Results: β-Endorphin concentrations were significantly lower in patients with chronic fatigue syndrome or fibromyalgia syndrome than in normal subjects and depressed patients (p

Original languageEnglish
Pages (from-to)270-273
Number of pages4
JournalClinical Journal of Pain
Volume18
Issue number4
DOIs
Publication statusPublished - 2002

Keywords

  • β-endorphin concentrations
  • Chronic fatigue syndrome
  • Depression
  • Fibromyalgia syndrome
  • Immune system
  • Peripheral blood mononuclear cells

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

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