Peripheral blood progenitor cell mobilization is significantly enhanced by amifostine

C. Carlo-Stella, A. Dodero, L. Mangoni, V. Franciosi, B. Di Blasio, R. Passalacqua, G. Cocconi, V. Rizznli

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Mobilization protocols of peripheral blood progenitor cells (PBPCs) include the administration of growth factors alone or during the recovery from chemotherapy. Protocols that mobilize increased numbers of PBPCs are being investigated. Amifostine (AMI), a phosphorylated aminothiol, increases the selectivity of anticancer drugs for neoplastic cells, protects normal tissues from radio-chemotherapy toxicities and stimulates in vivo hematoppiesis. The aim of the present study was to investigate the role of AMI in conjunction with Epirubicin (EPI) and G-CSF to enhance PBPC mobilization. Ten patients with advanced solid tumors who were administered with two cycles of EPI (120 mg/sqm on day 0) plus G-CSF (5 |lg/kg/d, days 1-10) at 3-week interval were randomized to receive AMI on first or second cycle. AMI was administered i.v. for 5 days (day 0: 1,000 mg, days 1-4: 500 mg/d). Once daily, from day 0 to 10, white blood cell (WBC) and platelet (Pit) counts, CD34 cells, and progenitor cell incidence (CPU-Mix, BFU-E, CFU-GM, LTC-IC) were evaluated. Currently, eight patients (2 untreated and 6 pre-treated with 7 to 17 chemotherapy cycles) who received AMI at the first (n = 4) or second (n = 4) cycle are évaluable. WBC and Pit counts were not affected by AMI administration. In contrast, EPI+G-CSF+AMI compared to EPI+G-CSF induced a statistically significant (P

Original languageEnglish
Pages (from-to)708
Number of pages1
JournalExperimental Hematology
Issue number8
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation


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