La raccolta di cellule staminali periferiche nei tumori pediatrici

Confronto fra tre sistemi di mobilizzazione

Translated title of the contribution: Peripheral blood stem cell collection in pediatric malignancies: Comparison between three mobilizing regimens

M. D. De Pasquale, A. Cacchione, M. Foco, M. Gozzer, F. Libera, F. Soscia, G. Ragni, Carlo Cappelli

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: The optimal method for PBSC (peripheral blood stem cells) mobilization in pediatric patients is still unknow. The present study was conducted to evaluate the safety of apheresis procedures and to compare the efficacy of three methods of PBSC mobilization. Patients and methods: Our study was performed on 28 pediatric patients (in three groups) with solid tumors at onset or on relapse. In two groups we tried to mobilize PBSC administering CHT (based on Carboplatin with Etoposide in the first group and Cyclophosphamide in the second group) followed by granulocyte colony stimulating factor (G-CSF); in the third group the mobilization regimen was based on G-CSF alone. Results: Forty-nine mobilizations have been performed and a median of 6,5CD34+ cells × 10 6/Kg were collected, with a median number of one apheresis for each patient. Using Carboplatin with G-CSF and Cyclophosphamide with G-CSF we collected respectively a median value of 6,75 and 7,3 × 10 6 CD34+cells /kg. The mobilization method based on G-CSF alone showed to be less effective (median of 4,3 CD34+ cells × 10 6 /kg collected). Conclusions: In our experience the mobilizing regimens based on Carboplatin or Cyclophosphamide associated with G-CSF resulted both effective and better than the one based on G-CSF alone with a scanty number of apheresis procedures.

Original languageItalian
Pages (from-to)305-309
Number of pages5
JournalClinica Terapeutica
Volume154
Issue number5
Publication statusPublished - Sep 2003

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Granulocyte Colony-Stimulating Factor
Pediatrics
Blood Component Removal
Carboplatin
Neoplasms
Cyclophosphamide
Hematopoietic Stem Cell Mobilization
Etoposide
Peripheral Blood Stem Cells
Safety
Recurrence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

De Pasquale, M. D., Cacchione, A., Foco, M., Gozzer, M., Libera, F., Soscia, F., ... Cappelli, C. (2003). La raccolta di cellule staminali periferiche nei tumori pediatrici: Confronto fra tre sistemi di mobilizzazione. Clinica Terapeutica, 154(5), 305-309.

La raccolta di cellule staminali periferiche nei tumori pediatrici : Confronto fra tre sistemi di mobilizzazione. / De Pasquale, M. D.; Cacchione, A.; Foco, M.; Gozzer, M.; Libera, F.; Soscia, F.; Ragni, G.; Cappelli, Carlo.

In: Clinica Terapeutica, Vol. 154, No. 5, 09.2003, p. 305-309.

Research output: Contribution to journalArticle

De Pasquale, MD, Cacchione, A, Foco, M, Gozzer, M, Libera, F, Soscia, F, Ragni, G & Cappelli, C 2003, 'La raccolta di cellule staminali periferiche nei tumori pediatrici: Confronto fra tre sistemi di mobilizzazione', Clinica Terapeutica, vol. 154, no. 5, pp. 305-309.
De Pasquale, M. D. ; Cacchione, A. ; Foco, M. ; Gozzer, M. ; Libera, F. ; Soscia, F. ; Ragni, G. ; Cappelli, Carlo. / La raccolta di cellule staminali periferiche nei tumori pediatrici : Confronto fra tre sistemi di mobilizzazione. In: Clinica Terapeutica. 2003 ; Vol. 154, No. 5. pp. 305-309.
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