Peripheral blood stem cell graft compared to bone marrow after reduced intensity conditioning regimens for acute leukemia: A report from the alwp of the ebmt

Bipin N. Savani, Myriam Labopin, Didier Blaise, Dietger Niederwieser, Fabio Ciceri, Arnold Ganser, Renate Arnold, Boris Afanasyev, Stephane Vigouroux, Noel Milpied, Michael Hallek, Jan J. Cornelissen, Rainer Schwerdtfeger, Emmanuelle Polge, Frédéric Baron, Jordi Esteve, Norbert C. Gorin, Christoph Schmid, Sebastian Giebel, Mohamad MohtyArnon Nagler

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Abstract

Increasing numbers of patients are receiving reduced intensity conditioning regimen allogeneic hematopoietic stem cell transplantation. We hypothesized that the use of bone marrow graft might decrease the risk of graft-versus-host disease compared to peripheral blood after reduced intensity conditioning regimens without compromising graft-versus-leukemia effects. Patients who underwent reduced intensity conditioning regimen allogeneic hematopoietic stem cell transplantation from 2000 to 2012 for acute leukemia, and who were reported to the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation were included in the study. Eight hundred and thirty-seven patients receiving bone marrow grafts were compared with 9011 peripheral blood transplant recipients after reduced intensity conditioning regimen. Median follow up of surviving patients was 27 months. Cumulative incidence of engraftment (neutrophil ≥0.5x109/L at day 60) was lower in bone marrow recipients: 88% versus 95% (P

Original languageEnglish
Pages (from-to)256-262
Number of pages7
JournalHaematologica
Volume101
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

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ASJC Scopus subject areas

  • Hematology

Cite this

Savani, B. N., Labopin, M., Blaise, D., Niederwieser, D., Ciceri, F., Ganser, A., Arnold, R., Afanasyev, B., Vigouroux, S., Milpied, N., Hallek, M., Cornelissen, J. J., Schwerdtfeger, R., Polge, E., Baron, F., Esteve, J., Gorin, N. C., Schmid, C., Giebel, S., ... Nagler, A. (2016). Peripheral blood stem cell graft compared to bone marrow after reduced intensity conditioning regimens for acute leukemia: A report from the alwp of the ebmt. Haematologica, 101(2), 256-262. https://doi.org/10.3324/haematol.2015.135699