Peripheral blood stem cells in children with solid tumors: Part II - Immunocytologic detection of tumor cells in bone marrow and peripheral blood stem cell harvests

C. Dominici, G. Deb, A. Angioni, A. Landolfo, F. Parisi, L. Helson, A. Donfrancesco

Research output: Contribution to journalArticle

Abstract

Simultaneous comparative assessment of tumor contamination in bone marrow aspirates and peripheral blood stem cell collections using immunocytochemical techniques was done in 6 children with neuroectodermal tumors. In 3 neuroblastoma patients tumor cells were detected in 5 of 16 marrow samples but not in peripheral blood stem cells. Clonogenic tumor cell reinfusion in the autologous support setting may be avoided in neuroblastoma patients by using peripheral blood stem cells.

Original languageEnglish
Pages (from-to)2573-2575
Number of pages3
JournalAnticancer Research
Volume13
Issue number6 B
Publication statusPublished - 1993

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Keywords

  • Autologous peripheral blood stem cells
  • Bone marrow
  • Immunocytologic analysis
  • Pediatric apheresis
  • Tumor cell contamination

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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