Peripheral cytokine release in Alzheimer patients: Correlation with disease severity

Gessica Sala, Gloria Galimberti, Carla Canevari, Maria Elisabetta Raggi, Valeria Isella, Maurizio Facheris, Ildebrando Appollonio, Carlo Ferrarese

Research output: Contribution to journalArticlepeer-review


Various studies suggested that inflammation is involved in the pathogenesis of Alzheimer's disease (AD). We investigated cytokine release from LPS-stimulated blood cells of 32 AD patients, with different disease severity, compared to 16 age-related controls. A significant decrease of IL-1beta and IL-6 secretion was observed in severely demented patients; TNF-alpha release was also decreased, but not significantly. By contrast, mild and moderate patients showed a cytokine release similar to controls. IL-1beta, IL-6 and TNF-alpha secretion was negatively correlated with the severity of dementia, quantified by the MMSE. Our data suggest that alterations of the immune profile are associated with AD progression.

Original languageEnglish
Pages (from-to)909-914
Number of pages6
JournalNeurobiology of Aging
Issue number7
Publication statusPublished - Nov 2003


  • Alzheimer's disease
  • Disease severity
  • Inflammation
  • Peripheral cytokine release

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)


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