Peripheral development of B cells in mouse and man

Rita Carsetti, M. Manuela Rosado, Hedda Wardemann

Research output: Contribution to journalArticle

Abstract

In man and in mouse, B-cell maturation occurs in steps, first in the bone marrow from hematopoietic precursors to immature/transitional B cells, then in the periphery from transitional to fully mature B cells. Each developmental step is tightly controlled by the expression and function of the B-cell receptor (BCR) and by the ability to interact with the microenvironment. Mature B cells collaborate with T cells in the adaptive immune response, leading to the production of high-affinity antibodies. This response is very accurate, but slow. Immediately after pathogen entry, however, antibodies already present in the serum reinforce the innate immune response and contribute to the first-line defense against infection. Low-affinity natural antibodies are produced by B-1a B cells in the mouse and immunoglobulin M (IgM) memory cells in man. These antibodies represent an immediate protection against all microorganisms and the only one against encapsulated bacteria. B-1a and IgM memory B cells may function as a link between the innate and adaptive immune response and thus perform a primordial B-cell function.

Original languageEnglish
Pages (from-to)179-191
Number of pages13
JournalImmunological Reviews
Volume197
DOIs
Publication statusPublished - Jan 2004

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B-Lymphocytes
Antibody Affinity
B-Lymphoid Precursor Cells
Adaptive Immunity
Innate Immunity
Immunoglobulin M
Antibodies
Bone Marrow
Bacteria
T-Lymphocytes
Infection
Serum

ASJC Scopus subject areas

  • Immunology

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Peripheral development of B cells in mouse and man. / Carsetti, Rita; Rosado, M. Manuela; Wardemann, Hedda.

In: Immunological Reviews, Vol. 197, 01.2004, p. 179-191.

Research output: Contribution to journalArticle

Carsetti, Rita ; Rosado, M. Manuela ; Wardemann, Hedda. / Peripheral development of B cells in mouse and man. In: Immunological Reviews. 2004 ; Vol. 197. pp. 179-191.
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