Peripheral giant cell granuloma: Evidence for osteoclastic differentiation

Franco Bonetti, Giuseppe Pelosi, Guido Martignoni, Aldo Mombello, Giuseppe Zamboni, Maurizio Pea, Aldo Scarpa, Marco Chilosi

Research output: Contribution to journalArticlepeer-review


Nine cases of peripheral giant cell granuloma of the oral cavity have been immunohistochemically analyzed to assess the nature of the giant cells. Giant cells were unreactive when tested with antibodies recognizing myelomonocytic and macrophage markers (lysozyme, MAC 387, HAM 56) but showed strong immunoreactivity with MB 1, an antibody reactive with osteoclasts. It is concluded that giant cells characterizing giant cell granuloma exhibit a phenotype distinct from other giant cells found in sites of chronic inflammation and may be true osteoclasts.

Original languageEnglish
Pages (from-to)471-475
Number of pages5
JournalOral Surgery, Oral Medicine, Oral Pathology
Issue number4
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dentistry(all)


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