Peripheral insulin-like factor 3 concentrations are reduced in men with type 2 diabetes mellitus: Effect of glycemic control and visceral adiposity on Leydig cell function

F. Ermetici, F. Donadio, L. Iorio, A. E. Malavazos, A. Dolci, E. Peverelli, A. M. Barbieri, L. Morricone, I. Chiodini, M. Arosio, A. Lania, P. Beck-Peccoz, B. Ambrosi, S. Corbetta

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Background and aim: Hypogonadism frequently occurs in men with type 2 diabetes mellitus (T2DM), while the role of glycemic control and visceral obesity is still unclear. This study aimed to assess the Leydig cell function, including the new sensitive marker insulin-like factor 3 (INSL3), in T2DM patients without overt hypogonadism and the influence of either glycemic control or visceral adiposity. Subjects and methods: Thirty T2DM patients (age 57.1±6.2 years, body mass index (BMI) 28.0±4.3) without overt hypogonadism and 30 age- and BMI-matched controls were studied. Anthropometric, glycometabolic parameters and testosterone, SHBG, LH, INSL3 levels, bioavailable and free testosterone (BT and cFT) were evaluated. The human chorionic gonadotrophin (hCG) test was also performed. Results: Patients had lower total testosterone (452.6±130.0 vs 512.6±117.3 ng/dl, P=0.06), BT (189.7±36.4 vs 237.1±94.1 ng/dl, P=0.002), cFT (8.1±1.6 vs 10.1±4.0 ng/dl, P=0.002), and higher LH levels (3.5±1.6 vs 2.6±1.2 mU/ml, P=0.01) versus controls. Serum INSL3 concentrations were also lower in patients (1.1±0.3 vs 1.5±0.7 ng/ml, P=0.01). These hormonal parameters, including INSL3, did not differ between T2DM patients with poor or good glycemic control (HbA1c>9 or

Original languageEnglish
Pages (from-to)853-859
Number of pages7
JournalEuropean Journal of Endocrinology
Issue number6
Publication statusPublished - 2009


ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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