Peripheral microcirculatory lesions in myotonic dystrophy, a light and an electron microscopic study on digital biopsies

R. Scelsi, P. Poggi, G. Nappi, G. Sandrini

Research output: Contribution to journalArticle

Abstract

Peripheral microcirculation was studied in digital biopsies of 8 patients affected by Steinert's disease and in 5 normal volunteers. In 5 patients in whom clinical and laboratory investigations exclude diabetes, hypertension and other angiopathy-inducing disease, light and electron microscopic studies demonstrated significant thickening of the capillary basement membrane similar to that observed in diabetic microangiopathy, and haemodynamic-proliferative arteriosclerotic changes in arterioles and arteriovenular anastomoses, unrelated to the young age of the patients. Statistical evaluations revealed a significant correlation between peripheral microvascular alterations and disease duration.

Original languageEnglish
Pages (from-to)137-148
Number of pages12
JournalActa Neurologica
Volume33
Issue number2
Publication statusPublished - 1978

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ASJC Scopus subject areas

  • Clinical Neurology

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