TY - JOUR
T1 - Peripheral nerve autografts to the injured spinal cord of the rat
T2 - An experimental model for the study of spinal cord regeneration
AU - Fernandez, E.
AU - Pallini, R.
AU - Maira, G.
AU - Rossi, G. F.
PY - 1985/3
Y1 - 1985/3
N2 - Regenerated central axons have been shown experimentally to penetrate in peripheral nerve segments transplanted into the spinal cord (SC). However, if the nerves are transplanted between the stumps of the transected SC regeneration is impaired by local cavitation and scarring. Our experiment was designed to study whether nerve grafts bridging a severe transverse SC lesion might provide to central regenerating axons a pathway to by-pass the lesion. To this purpose, 2 segments of autologous peripheral nerves were inserted through small dural openings into dorsal longitudinal myelotomies rostral and caudal to a transverse SC lesion in rats. Eighteen weeks after transplantation a large number of well myelinated fibres filled the grafted nerves. Only a few of these fibres, however, could be followed into the SC; they were located in the outer layers of the dorsal white matter. The problems regarding the origin and destination of these fibres are discussed.
AB - Regenerated central axons have been shown experimentally to penetrate in peripheral nerve segments transplanted into the spinal cord (SC). However, if the nerves are transplanted between the stumps of the transected SC regeneration is impaired by local cavitation and scarring. Our experiment was designed to study whether nerve grafts bridging a severe transverse SC lesion might provide to central regenerating axons a pathway to by-pass the lesion. To this purpose, 2 segments of autologous peripheral nerves were inserted through small dural openings into dorsal longitudinal myelotomies rostral and caudal to a transverse SC lesion in rats. Eighteen weeks after transplantation a large number of well myelinated fibres filled the grafted nerves. Only a few of these fibres, however, could be followed into the SC; they were located in the outer layers of the dorsal white matter. The problems regarding the origin and destination of these fibres are discussed.
KW - experimental cord injury
KW - method of assessment
KW - Peripheral nerve autografts
KW - rat spinal cord
UR - http://www.scopus.com/inward/record.url?scp=0022250193&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022250193&partnerID=8YFLogxK
U2 - 10.1007/BF01809242
DO - 10.1007/BF01809242
M3 - Article
C2 - 4072794
AN - SCOPUS:0022250193
VL - 78
SP - 57
EP - 64
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
SN - 0001-6268
IS - 1-2
ER -